Exogenous prostacyclin does not sensitize arterial baroreceptors

Yoshitaka Hirooka, S. I. Ando, T. Imaizumi, S. Suzuki, A. Takeshita

Research output: Contribution to journalArticle

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Abstract

It has been shown that prostacyclin (PGI2) sensitizes cardiac receptors. However, the effects of PGI2 on arterial baroreceptors are not well understood. In rabbits anesthetized with α-chloralose (n = 12), we examined reflex changes in multiunit efferent renal sympathetic nerve activity (RSNA) during hypotension caused by intravenous PGI2 (0.1, 0.2, 0.5, 1.0, 2.0 μg/kg), nitroglycerin (NG; 5, 10, 20, 50, 100 μg/kg), and sodium nitroprusside (SNP; 5, 10, 20, 50, 100 μg/kg) before and after bilateral vagotomy. Before vagotomy, RSNA increased during hypotension caused by NG or SNP (P < 0.01) but did not significantly change during comparable hypotension caused by PGI2. After vagotomy, PGI2 increased RSNA as much as NG or SNP. In another group (n = 6), we examined the changes in aortic pressure (AoP), multiunit afferent aortic nerve activity (ANA), and the aortic diameter (AoD) during hypotension caused by intravenous PGI2, NG, and SNP. The relationship between changes in AoP and those in ANA did not differ during hypotension caused by the three drugs. The relationship between changes in AoP and those in AoD and that between changes in AoD and those in ANA also did not differ. Finally, we examined changes in AoP, ANA, and AoD during ramp increases or decreases of AoP caused by intravenous angiotensin II or NG under background infusion of saline, PGI2, or SNP (n = 6). The relationship among these variables did not differ during infusion of PGI2 and SNP. These results suggest that PGI2 stimulates cardiac receptors with vagal afferents but does not sensitize arterial baroreceptors.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume260
Issue number6 29-6
Publication statusPublished - Jan 1 1991

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Pressoreceptors
Epoprostenol
Single Nucleotide Polymorphism
Hypotension
Arterial Pressure
Vagotomy
Kidney
Chloralose
Architectural Accessibility
Nitroglycerin
Nitroprusside
Angiotensin II
Reflex
Rabbits

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hirooka, Y., Ando, S. I., Imaizumi, T., Suzuki, S., & Takeshita, A. (1991). Exogenous prostacyclin does not sensitize arterial baroreceptors. American Journal of Physiology - Heart and Circulatory Physiology, 260(6 29-6).

Exogenous prostacyclin does not sensitize arterial baroreceptors. / Hirooka, Yoshitaka; Ando, S. I.; Imaizumi, T.; Suzuki, S.; Takeshita, A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 260, No. 6 29-6, 01.01.1991.

Research output: Contribution to journalArticle

Hirooka, Y, Ando, SI, Imaizumi, T, Suzuki, S & Takeshita, A 1991, 'Exogenous prostacyclin does not sensitize arterial baroreceptors', American Journal of Physiology - Heart and Circulatory Physiology, vol. 260, no. 6 29-6.
Hirooka, Yoshitaka ; Ando, S. I. ; Imaizumi, T. ; Suzuki, S. ; Takeshita, A. / Exogenous prostacyclin does not sensitize arterial baroreceptors. In: American Journal of Physiology - Heart and Circulatory Physiology. 1991 ; Vol. 260, No. 6 29-6.
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