Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

M. Koyama, D. Hashimoto, K. Nagafuji, T. Eto, Y. Ohno, K. Aoyama, H. Iwasaki, T. Miyamoto, G. R. Hill, K. Akashi, T. Teshima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalBone Marrow Transplantation
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

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Graft Rejection
Tissue Donors
T-Lymphocytes
Transplants
Fetal Blood
Transplantation
Dendritic Cells
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning. / Koyama, M.; Hashimoto, D.; Nagafuji, K.; Eto, T.; Ohno, Y.; Aoyama, K.; Iwasaki, H.; Miyamoto, T.; Hill, G. R.; Akashi, K.; Teshima, T.

In: Bone Marrow Transplantation, Vol. 49, No. 1, 01.01.2014, p. 110-115.

Research output: Contribution to journalArticle

Koyama, M. ; Hashimoto, D. ; Nagafuji, K. ; Eto, T. ; Ohno, Y. ; Aoyama, K. ; Iwasaki, H. ; Miyamoto, T. ; Hill, G. R. ; Akashi, K. ; Teshima, T. / Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning. In: Bone Marrow Transplantation. 2014 ; Vol. 49, No. 1. pp. 110-115.
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AU - Ohno, Y.

AU - Aoyama, K.

AU - Iwasaki, H.

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AU - Hill, G. R.

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