Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules

Tsuyoshi Muta, Tomoyasu Yoshihiro, Fumiaki Jinnouchi, Kenichi Aoki, Yu Kochi, Takahiro Shima, Katsuto Takenaka, Ryosuke Ogawa, Koichi Akashi, Koichi Oshima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial remission state after the administration of salvage chemotherapy. The donor-derived large granular lymphocytes started to increase as a result of cytomegalovirus reactivation. The fraction of natural killer (NK) cells expressing the NKG2C molecule accounted for one-third of the total lymphocytes for almost two years. We implicitly indicate the association between the persistence of donor-derived NKG2C+ NK cell-expansion and maintaining a complete remission in similar cases of aggressive PTCL-NOS.

Original languageEnglish
Pages (from-to)861-866
Number of pages6
JournalInternal Medicine
Volume57
Issue number6
DOIs
Publication statusPublished - Jan 1 2018

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Peripheral T-Cell Lymphoma
Fetal Blood
Natural Killer Cells
Transplantation
Tissue Donors
Lymphocytes
Cytomegalovirus
Biopsy
Drug Therapy
Lymphadenopathy

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules. / Muta, Tsuyoshi; Yoshihiro, Tomoyasu; Jinnouchi, Fumiaki; Aoki, Kenichi; Kochi, Yu; Shima, Takahiro; Takenaka, Katsuto; Ogawa, Ryosuke; Akashi, Koichi; Oshima, Koichi.

In: Internal Medicine, Vol. 57, No. 6, 01.01.2018, p. 861-866.

Research output: Contribution to journalArticle

Muta, Tsuyoshi ; Yoshihiro, Tomoyasu ; Jinnouchi, Fumiaki ; Aoki, Kenichi ; Kochi, Yu ; Shima, Takahiro ; Takenaka, Katsuto ; Ogawa, Ryosuke ; Akashi, Koichi ; Oshima, Koichi. / Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules. In: Internal Medicine. 2018 ; Vol. 57, No. 6. pp. 861-866.
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AU - Jinnouchi, Fumiaki

AU - Aoki, Kenichi

AU - Kochi, Yu

AU - Shima, Takahiro

AU - Takenaka, Katsuto

AU - Ogawa, Ryosuke

AU - Akashi, Koichi

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