Expansion of the zinc metallo-hydrolase family of the β-lactamase fold

Hiromi Daiyasu, Kazuya Osaka, Yoshizumi Ishino, Hiroyuki Toh

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Recently, the zinc metallo-hydrolase family of the β-lactamase fold has grown quite rapidly, accompanied by the accumulation of sequence and structure data. The variety of the biological functions of the family is higher than expected. In addition, the members often have mosaic structures with additional domains. The family includes class B β-lactamase, glyoxalase II, arylsulfatase, flavoprotein, cyclase/dehydrase, an mRNA 3′-processing protein, a DNA cross-link repair enzyme, a DNA uptake-related protein, an alkylphosphonate uptake-related protein, CMP-N-acetylneuraminate hydroxylase, the romA gene product, alkylsulfatase, and insecticide hydrolases. In this minireview, the functional and structural varieties of the growing protein family are described.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalFEBS Letters
Volume503
Issue number1
DOIs
Publication statusPublished - Aug 10 2001

Fingerprint

Hydrolases
Zinc
hydroxyacylglutathione hydrolase
Proteins
Arylsulfatases
DNA Repair Enzymes
Cytidine Monophosphate
Flavoproteins
DNA
Insecticides
Mixed Function Oxygenases
Repair
Genes
Messenger RNA
Enzymes
Processing

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Expansion of the zinc metallo-hydrolase family of the β-lactamase fold. / Daiyasu, Hiromi; Osaka, Kazuya; Ishino, Yoshizumi; Toh, Hiroyuki.

In: FEBS Letters, Vol. 503, No. 1, 10.08.2001, p. 1-6.

Research output: Contribution to journalArticle

Daiyasu, Hiromi ; Osaka, Kazuya ; Ishino, Yoshizumi ; Toh, Hiroyuki. / Expansion of the zinc metallo-hydrolase family of the β-lactamase fold. In: FEBS Letters. 2001 ; Vol. 503, No. 1. pp. 1-6.
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