Experimental evaluation of validity of simplified Monte Carlo method in proton dose calculations

Ryosuke Kohno, Yoshihisa Takada, Takeji Sakae, Toshiyuki Terunuma, Keiji Matsumoto, Akihiro Nohtomi, Hiroyuki Matsuda

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


It is important for proton therapy to calculate dose distributions accurately in treatment planning. Dose calculations in the body for treatment planning are converted to dose distributions in water, and the converted calculations are then generally evaluated by the dose measurements in water. In this paper, proton dose calculations were realized for a phantom simulating a clinical heterogeneity. Both dose calculations in the phantom calculated by two dose calculation methods, the range-modulated pencil beam algorithm (RMPBA) and the simplified Monte Carlo (SMC) method, and dose calculations converted to dose distributions in water by the same two methods were verified experimentally through comparison with measured distributions, respectively. For the RMPBA, though the converted calculations in water agreed moderately well with the measured ones, the calculated results in the actual phantom produced large errors. This meant that dose calculations in treatment planning should be evaluated by the dose measurements not in water but in the body with heterogeneity. On the other hand, the results calculated in the phantom, even by the less rigorous SMC method, reproduced the experimental ones well. This finding showed that actual dose distributions in the body should be predicted by the SMC method.

Original languageEnglish
Pages (from-to)1277-1288
Number of pages12
JournalPhysics in Medicine and Biology
Issue number10
Publication statusPublished - May 21 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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