Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus

Tadahiro Nozoe, Mitsuhiro Yasuda, Masayuki Honda, Sadaaki Imutsuka, Daisuke Korenaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: The aim of the current study was to show an anti-tumor effect for esophageal squamous carcinoma cells derived from a combination of hyperthermia and CPT-11, which would ultimately lead to the clinical usage of this therapeutic modality for patients with squamous cell carcinoma of the esophagus. Methodology: Survival fraction of esophageal squamous carcinoma cells after administrating SN-38, active metabolite of CPT-11, and combination of hyperthermia and SN-38 was compared using data measured by MTT assay. Results: Reduction of cell survival fraction derived by simultaneous induction of hyperthermia and SN-38, in many combinations of the temperature and charging period, was significantly greater than that acquired by SN-38 alone. Conclusions: Combination of hyperthermia and CPT-11 can exert a synergic anti-tumor efficacy for SCC of the esophagus.

Original languageEnglish
Pages (from-to)2272-2275
Number of pages4
JournalHepato-gastroenterology
Volume54
Issue number80
Publication statusPublished - Dec 1 2007

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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