TY - JOUR
T1 - Experimental Evidence of Slow Mode Water in the Vicinity of Poly(ethylene oxide) at Physiological Temperature
AU - Tominaga, Taiki
AU - Hishida, Mafumi
AU - Murakami, Daiki
AU - Fujii, Yoshihisa
AU - Tanaka, Masaru
AU - Seto, Hideki
N1 - Funding Information:
The authors thank Dr. Takeshi Yamada for experimental support and discussion. The neutron experiments at MLF were conducted under a user program (Proposal Nos. 2018B0235 and 2020A0221). This work was supported by Grants-in-Aid for Scientific Research on Innovative Areas Nos. JP19H05717 and JP19H05720 (Aquatic Functional Materials).
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/3/3
Y1 - 2022/3/3
N2 - In some synthetic polymers used for medical applications, hydration water in the vicinity of the polymer chains is known to play an important role in biocompatibility and is referred to as intermediate water. The crystallization of water below 0 °C observed during thermal analysis has been considered as evidence of the presence of intermediate water. However, the origin and physicochemical properties of intermediate water have not yet been elucidated. In this study, as a typical biocompatible polymer, poly(ethylene oxide) and its hydration water were investigated with the use of terahertz time-domain spectroscopy and quasi-elastic neutron scattering. The obtained results prove the existence of a significant amount of mobile water that interacts with the polymer chains even when the water content is low at physiological temperatures.
AB - In some synthetic polymers used for medical applications, hydration water in the vicinity of the polymer chains is known to play an important role in biocompatibility and is referred to as intermediate water. The crystallization of water below 0 °C observed during thermal analysis has been considered as evidence of the presence of intermediate water. However, the origin and physicochemical properties of intermediate water have not yet been elucidated. In this study, as a typical biocompatible polymer, poly(ethylene oxide) and its hydration water were investigated with the use of terahertz time-domain spectroscopy and quasi-elastic neutron scattering. The obtained results prove the existence of a significant amount of mobile water that interacts with the polymer chains even when the water content is low at physiological temperatures.
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U2 - 10.1021/acs.jpcb.1c09044
DO - 10.1021/acs.jpcb.1c09044
M3 - Article
C2 - 35193352
AN - SCOPUS:85125681801
SN - 1520-6106
VL - 126
SP - 1758
EP - 1767
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
IS - 8
ER -