Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem

Takuya Kishi, K. Sunagawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including the abnormal autonomic nervous system. We have demonstrated that the oxidative stress through AT 1 receptor in the brain activates sympathetic nervous system. The aim of the present study was to determine whether experimental jet lag causes sympathoexcitation via oxidative stress through AT 1 receptor in the cardiovascular center of the brainstem (rostral ventrolateral medulla; RVLM) or not. Experimental jet lag was made to normotensive (Wister-Kyoto rat; WKY rat) and hypertensive rats (stroke-prone spontaneously hypertensive rats; SHRSP) by the exposure to a 12 hour phase advance for 5 days. In WKY, jet lag increases blood pressure and the activity of sympathetic nervous system via oxidative stress through angiotensin II type 1 receptor in the RVLM for 2 days only, and the changes are improved at 3 day after the initiation of jet lag. In SHRSP, jet lag also increases blood pressure and the activity of sympathetic nervous system via oxidative stress through angiotensin II type 1 receptor in the RVLM, and the changes are greater compared to those in WKY, and are maintained for the period of jet lag. These results suggest that experimental jet lag causes sympathoexcitation via oxidative stress through AT 1 receptor in the brain, especially in hypertension.

Original languageEnglish
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages1969-1972
Number of pages4
DOIs
Publication statusPublished - Dec 26 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: Aug 30 2011Sep 3 2011

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period8/30/119/3/11

Fingerprint

Oxidative stress
Brain Stem
Oxidative Stress
Sympathetic Nervous System
Neurology
Rats
Angiotensin Type 1 Receptor
Blood pressure
Blood Pressure
Brain
Inbred WKY Rats
Autonomic Nervous System
Inbred SHR Rats
Mental Health
Stroke
Hypertension
Health

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Kishi, T., & Sunagawa, K. (2011). Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 1969-1972). [6090555] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090555

Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem. / Kishi, Takuya; Sunagawa, K.

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 1969-1972 6090555 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kishi, T & Sunagawa, K 2011, Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6090555, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 1969-1972, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6090555
Kishi T, Sunagawa K. Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 1969-1972. 6090555. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090555
Kishi, Takuya ; Sunagawa, K. / Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. pp. 1969-1972 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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