Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT 1 receptor in the brainstem

T. Kishi, K. Sunagawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    8 Citations (Scopus)

    Abstract

    Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including the abnormal autonomic nervous system. We have demonstrated that the oxidative stress through AT 1 receptor in the brain activates sympathetic nervous system. The aim of the present study was to determine whether experimental jet lag causes sympathoexcitation via oxidative stress through AT 1 receptor in the cardiovascular center of the brainstem (rostral ventrolateral medulla; RVLM) or not. Experimental jet lag was made to normotensive (Wister-Kyoto rat; WKY rat) and hypertensive rats (stroke-prone spontaneously hypertensive rats; SHRSP) by the exposure to a 12 hour phase advance for 5 days. In WKY, jet lag increases blood pressure and the activity of sympathetic nervous system via oxidative stress through angiotensin II type 1 receptor in the RVLM for 2 days only, and the changes are improved at 3 day after the initiation of jet lag. In SHRSP, jet lag also increases blood pressure and the activity of sympathetic nervous system via oxidative stress through angiotensin II type 1 receptor in the RVLM, and the changes are greater compared to those in WKY, and are maintained for the period of jet lag. These results suggest that experimental jet lag causes sympathoexcitation via oxidative stress through AT 1 receptor in the brain, especially in hypertension.

    Original languageEnglish
    Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
    Pages1969-1972
    Number of pages4
    DOIs
    Publication statusPublished - 2011
    Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
    Duration: Aug 30 2011Sep 3 2011

    Publication series

    NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    ISSN (Print)1557-170X

    Other

    Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
    CountryUnited States
    CityBoston, MA
    Period8/30/119/3/11

    All Science Journal Classification (ASJC) codes

    • Signal Processing
    • Biomedical Engineering
    • Computer Vision and Pattern Recognition
    • Health Informatics

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