Crown-bridged calixquinones (5 and 6) were synthesized from calixcrown (2). The ion-selective electrodes prepared from 5 or 6 still retained high selectivity for Na+ against K+ (>103). For protein solution samples the electrode prepared from 2 showed a large phase divergence whereas those prepared from 5 or 6 were much more stable in protein solution. The difference is attributed to the less hydrophobic nature of 5 and 6 which strongly influences the protein adsorption onto the membrane surface.
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