Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat

Kazuhiko Kubo, Okio Arai, Rika Ogata, Minoru Omura, Tetsuro Hori, Shuji Aou

Research output: Contribution to journalArticlepeer-review

129 Citations (Scopus)

Abstract

This study tested the effect of exposure to bisphenol A (BPA) early in life on the sexual differentiation in the brain and behavior in Wistar rats. We administered BPA only to mother rats during pregnancy and lactation at a dosage of approximately 1.5 mg/kg per day far less than the no-observed-adverse-effect level (NOAEL; 50 mg/kg per day). Control female offspring showed a higher activity, a lower avoidance memory, and larger locus coeruleus than the male controls, while the BPA-exposed group did not show any sexual dimorphism. BPA did not affect the reproductive organs or sex hormones. Our results suggest that the current methods to determine the NOAEL of artificial industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalNeuroscience Letters
Volume304
Issue number1-2
DOIs
Publication statusPublished - May 18 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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