TY - JOUR
T1 - Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo
T2 - a register-based study
AU - Michikawa, Takehiro
AU - Morokuma, Seiichi
AU - Yamazaki, Shin
AU - Takami, Akinori
AU - Sugata, Seiji
AU - Yoshino, Ayako
AU - Takeda, Yuki
AU - Nakahara, Kazushige
AU - Saito, Shinji
AU - Hoshi, Junya
AU - Kato, Kiyoko
AU - Nitta, Hiroshi
AU - Nishiwaki, Yuji
N1 - Funding Information:
Funding This study was supported by the Japan Society for the Promotion of Science KAKENHI [grant number 18H03388]. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Publisher Copyright:
© 2021, The Author(s).
PY - 2022/1
Y1 - 2022/1
N2 - Background: Maternal exposure to fine particulate matter (PM2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM2.5 are more harmful for maternal and foetal health. Objective: We focused on exposure over the first trimester (0–13 weeks of gestation), which includes the early placentation period, and investigated whether PM2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth). Methods: From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton infants within 23 Tokyo wards (≈627 km2). Using daily filter sampling of PM2.5 at one monitoring location, we analysed carbon and ion components, and assigned the first trimester average of the respective pollutant concentrations to each woman. Results: The ORs of placenta-mediated pregnancy complications were 1.14 (95% CI = 1.08–1.22) per 0.51 μg/m3 (interquartile range) increase of organic carbon and 1.11 (1.03–1.18) per 0.06 μg/m3 increase of sodium. Organic carbon was also associated with four individual complications. There was no association between ozone and outcome. Significance: There were specific components of PM2.5 that have adverse effects on maternal and foetal health.
AB - Background: Maternal exposure to fine particulate matter (PM2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM2.5 are more harmful for maternal and foetal health. Objective: We focused on exposure over the first trimester (0–13 weeks of gestation), which includes the early placentation period, and investigated whether PM2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth). Methods: From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton infants within 23 Tokyo wards (≈627 km2). Using daily filter sampling of PM2.5 at one monitoring location, we analysed carbon and ion components, and assigned the first trimester average of the respective pollutant concentrations to each woman. Results: The ORs of placenta-mediated pregnancy complications were 1.14 (95% CI = 1.08–1.22) per 0.51 μg/m3 (interquartile range) increase of organic carbon and 1.11 (1.03–1.18) per 0.06 μg/m3 increase of sodium. Organic carbon was also associated with four individual complications. There was no association between ozone and outcome. Significance: There were specific components of PM2.5 that have adverse effects on maternal and foetal health.
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U2 - 10.1038/s41370-021-00299-4
DO - 10.1038/s41370-021-00299-4
M3 - Article
C2 - 33603097
AN - SCOPUS:85101283836
SN - 1559-0631
VL - 32
SP - 135
EP - 145
JO - Journal of Exposure Science and Environmental Epidemiology
JF - Journal of Exposure Science and Environmental Epidemiology
IS - 1
ER -
