TY - JOUR
T1 - Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain
AU - Ishizuka, Koko
AU - Igata-Yi, Ruriko
AU - Kimura, Takemi
AU - Hieshima, Kunio
AU - Kukita, Toshio
AU - Kin, Yosiaki
AU - Misumi, Yoshio
AU - Yamamoto, Masaaki
AU - Nomiyama, Hisayuki
AU - Miura, Retsu
AU - Takamatsu, Junichi
AU - Katsuragi, Shoichi
AU - Miyakawa, Taihei
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.
AB - Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.
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U2 - 10.1097/00001756-199703240-00031
DO - 10.1097/00001756-199703240-00031
M3 - Article
C2 - 9175116
AN - SCOPUS:0011304076
SN - 0959-4965
VL - 8
SP - 1215
EP - 1218
JO - NeuroReport
JF - NeuroReport
IS - 5
ER -
