Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Koko Ishizuka, Ruriko Igata-Yi, Takemi Kimura, Kunio Hieshima, Toshio Kukita, Yosiaki Kin, Yoshio Misumi, Masaaki Yamamoto, Hisayuki Nomiyama, Retsu Miura, Junichi Takamatsu, Shoichi Katsuragi, Taihei Miyakawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

Original languageEnglish
Pages (from-to)1215-1218
Number of pages4
JournalNeuroReport
Volume8
Issue number5
DOIs
Publication statusPublished - Jan 1 1997

Fingerprint

Macrophage Inflammatory Proteins
CC Chemokines
Neuroglia
Brain
Schizophrenia
Neurons
Messenger RNA
Chemokines
Northern Blotting
In Situ Hybridization
Leukocytes
Inflammation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain. / Ishizuka, Koko; Igata-Yi, Ruriko; Kimura, Takemi; Hieshima, Kunio; Kukita, Toshio; Kin, Yosiaki; Misumi, Yoshio; Yamamoto, Masaaki; Nomiyama, Hisayuki; Miura, Retsu; Takamatsu, Junichi; Katsuragi, Shoichi; Miyakawa, Taihei.

In: NeuroReport, Vol. 8, No. 5, 01.01.1997, p. 1215-1218.

Research output: Contribution to journalArticle

Ishizuka, K, Igata-Yi, R, Kimura, T, Hieshima, K, Kukita, T, Kin, Y, Misumi, Y, Yamamoto, M, Nomiyama, H, Miura, R, Takamatsu, J, Katsuragi, S & Miyakawa, T 1997, 'Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain', NeuroReport, vol. 8, no. 5, pp. 1215-1218. https://doi.org/10.1097/00001756-199703240-00031
Ishizuka, Koko ; Igata-Yi, Ruriko ; Kimura, Takemi ; Hieshima, Kunio ; Kukita, Toshio ; Kin, Yosiaki ; Misumi, Yoshio ; Yamamoto, Masaaki ; Nomiyama, Hisayuki ; Miura, Retsu ; Takamatsu, Junichi ; Katsuragi, Shoichi ; Miyakawa, Taihei. / Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain. In: NeuroReport. 1997 ; Vol. 8, No. 5. pp. 1215-1218.
@article{6c5aa86502714e75946d38cf3f9d8c4e,
title = "Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain",
abstract = "Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.",
author = "Koko Ishizuka and Ruriko Igata-Yi and Takemi Kimura and Kunio Hieshima and Toshio Kukita and Yosiaki Kin and Yoshio Misumi and Masaaki Yamamoto and Hisayuki Nomiyama and Retsu Miura and Junichi Takamatsu and Shoichi Katsuragi and Taihei Miyakawa",
year = "1997",
month = "1",
day = "1",
doi = "10.1097/00001756-199703240-00031",
language = "English",
volume = "8",
pages = "1215--1218",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

AU - Ishizuka, Koko

AU - Igata-Yi, Ruriko

AU - Kimura, Takemi

AU - Hieshima, Kunio

AU - Kukita, Toshio

AU - Kin, Yosiaki

AU - Misumi, Yoshio

AU - Yamamoto, Masaaki

AU - Nomiyama, Hisayuki

AU - Miura, Retsu

AU - Takamatsu, Junichi

AU - Katsuragi, Shoichi

AU - Miyakawa, Taihei

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

AB - Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

UR - http://www.scopus.com/inward/record.url?scp=0011304076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0011304076&partnerID=8YFLogxK

U2 - 10.1097/00001756-199703240-00031

DO - 10.1097/00001756-199703240-00031

M3 - Article

C2 - 9175116

AN - SCOPUS:0011304076

VL - 8

SP - 1215

EP - 1218

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 5

ER -