Expression of αβ-crystallin in the developing rat kidney

Toru Iwaki, Akiko Iwaki, Ronald K.H. Liem, James E. Goldman

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

The expression and cellular localization of αβ-crystallin during rat renal development was studied by Northern blot analysis and by immunocytochemistry. Northern blotting of total RNA extracted from whole kidneys revealed that the messenger RNA for αβ-crystallin rapidly increased after birth to reach adult levels by 20 days. At the same time, immunohistochemistry for αβ-crystallin demonstrated that the prominent elongation of Henle's loop during the first 10 days of life was accompanied by increased αβ-crystallin expression. Thus, the development of αβ-crystallin expression is correlated temporally with the acquisition of tubule function in early post-natal life.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalKidney International
Volume40
Issue number1
DOIs
Publication statusPublished - Jul 1991

All Science Journal Classification (ASJC) codes

  • Nephrology

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