Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

Jiro Fukae, Masashi Takanashi, Shin Ichiro Kubo, Ken Ichi Nishioka, Yusaku Nakabeppu, Hideo Mori, Yoshikuni Mizuno, Nobutaka Hattori

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.

Original languageEnglish
Pages (from-to)256-262
Number of pages7
JournalActa neuropathologica
Volume109
Issue number3
DOIs
Publication statusPublished - Apr 1 2005

Fingerprint

DNA Glycosylases
Neurodegenerative Diseases
Parkinson Disease
Substantia Nigra
Oxidative Stress
DNA Repair Enzymes
Progressive Supranuclear Palsy
8-hydroxyguanine
Protein Isoforms
Western Blotting
DNA
Brain
Enzymes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. / Fukae, Jiro; Takanashi, Masashi; Kubo, Shin Ichiro; Nishioka, Ken Ichi; Nakabeppu, Yusaku; Mori, Hideo; Mizuno, Yoshikuni; Hattori, Nobutaka.

In: Acta neuropathologica, Vol. 109, No. 3, 01.04.2005, p. 256-262.

Research output: Contribution to journalArticle

Fukae, Jiro ; Takanashi, Masashi ; Kubo, Shin Ichiro ; Nishioka, Ken Ichi ; Nakabeppu, Yusaku ; Mori, Hideo ; Mizuno, Yoshikuni ; Hattori, Nobutaka. / Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. In: Acta neuropathologica. 2005 ; Vol. 109, No. 3. pp. 256-262.
@article{9578f2a5d3aa4693a909280a6d6749c4,
title = "Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders",
abstract = "Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.",
author = "Jiro Fukae and Masashi Takanashi and Kubo, {Shin Ichiro} and Nishioka, {Ken Ichi} and Yusaku Nakabeppu and Hideo Mori and Yoshikuni Mizuno and Nobutaka Hattori",
year = "2005",
month = "4",
day = "1",
doi = "10.1007/s00401-004-0937-9",
language = "English",
volume = "109",
pages = "256--262",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

AU - Fukae, Jiro

AU - Takanashi, Masashi

AU - Kubo, Shin Ichiro

AU - Nishioka, Ken Ichi

AU - Nakabeppu, Yusaku

AU - Mori, Hideo

AU - Mizuno, Yoshikuni

AU - Hattori, Nobutaka

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.

AB - Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.

UR - http://www.scopus.com/inward/record.url?scp=23844465238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23844465238&partnerID=8YFLogxK

U2 - 10.1007/s00401-004-0937-9

DO - 10.1007/s00401-004-0937-9

M3 - Article

C2 - 15841414

AN - SCOPUS:23844465238

VL - 109

SP - 256

EP - 262

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 3

ER -