Expression of a Vibrio parahaemolyticus toxin in Escherichia coli results in chromosomal DNA degradation

Jing Zhang, Saki Taniguchi, Hironori Ito, Kazuhiro Iiyama, Madoka Hino, Tsutomu Katayama, Makoto Kimura

Research output: Contribution to journalArticle

Abstract

A toxin-antitoxin system, vp1842/vp1843, locates within a superintegron on the Vibrio parahaemolyticus genome chromosome I whose toxin gene vp1843 encodes a DNA nicking endonuclease. We found that the vp1843 expression in Escherichia coli cells strongly induced chromosomal DNA degradation. On the basis of these observations, we discuss a possible physiological role of vp1842/vp1843 in V. parahaemolyticus.

Original languageEnglish
Pages (from-to)1937-1940
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number10
DOIs
Publication statusPublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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