Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum

Shunsuke Takahashi, Kenichi Kohashi, Hidetaka Yamamoto, Minako Hirahashi, Reiko Kumagai, Nobuyoshi Takizawa, Kazuhiko Nakamura, Yoshihiko Maehara, Masao Tanaka, Ryoichi Takayanagi, Yoshinao Oda

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Summary Medullary carcinoma (MC) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 poorly differentiated adenocarcinomas (PDAs). The expressions of membranous E-cadherin (P <.0001), β-catenin (P <.0001) and claudin 1 (P =.0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the PDAs. E-cadherin membranous expression was also significantly preserved in the central portion of the MCs (P =.0178). Nuclear β-catenin expression in both the central portion (P =.0463) and invasive front (P =.0346) of the MCs was significantly less frequent compared to that in the PDAs. Snail (P =.0035) and Twist1 (P =.0463) expressions in the invasive front of the MCs were significantly less frequent compared to the PDAs, suggesting that the EMT phenomenon may occur rarely in colorectal MC. Reduced membranous E-cadherin expression in the MC central portion was significantly correlated with poor clinical outcome (P =.0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of E-cadherin in the central portion might be a good biomarker for an unfavorable prognosis in cases of MC.

Original languageEnglish
Pages (from-to)1257-1266
Number of pages10
JournalHuman Pathology
Volume46
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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