Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis

Yasunobu Abe, Koichi Ohshima, Manabu Nakashima, Keiichi Hara, Takamitsu Matsushima, Ilseung Choi, Junji Nishimura, Masahiro Kikuch, Hajime Nawata, Takeshi Watanabe, Koichiro Muta

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Abstract

Receptor-binding cancer antigen expressed on SiSo cells (RCAS1), which is recognized by the 22-1-1 monoclonal antibody (MoAb) against human uterine adenocarcinoma cell line SiSo, has been identified on various kinds of cancer cells. RCAS1 appears to be an apoptosis-associated protein that induces apoptosis in activated T-cells and erythroid progenitor cells. We previously demonstrated that monocytes/macrophages express RCAS1. In the present study, we investigated RCAS1 expression by 22-1-1 MoAb in histiocytic necrotizing lymphadenitis (HNL), which is characterized by necrotic lesions consisting of T-cells undergoing apoptosis and macrophages in proliferation. Expression of RCAS1 was analyzed by immunohistochemical staining in 9 cases of HNL and in 9 cases of reactive lymphadenitis used as a control. The ratio of RCAS1 + cells to CD68 + cells (monocytes/macrophages) was significantly higher in the patients with HNL than in the patients with reactive lymphadenitis (P=.0002;paired t test). Our findings suggest that RCAS1 expressed on macrophages may play an important role in the induction of activated T-cell apoptosis in cases of HNL.

Original languageEnglish
Pages (from-to)359-363
Number of pages5
JournalInternational journal of hematology
Volume77
Issue number4
DOIs
Publication statusPublished - May 2003

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All Science Journal Classification (ASJC) codes

  • Hematology

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