TY - JOUR
T1 - Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis
AU - Abe, Yasunobu
AU - Ohshima, Koichi
AU - Nakashima, Manabu
AU - Hara, Keiichi
AU - Matsushima, Takamitsu
AU - Choi, Ilseung
AU - Nishimura, Junji
AU - Kikuch, Masahiro
AU - Nawata, Hajime
AU - Watanabe, Takeshi
AU - Muta, Koichiro
PY - 2003/5
Y1 - 2003/5
N2 - Receptor-binding cancer antigen expressed on SiSo cells (RCAS1), which is recognized by the 22-1-1 monoclonal antibody (MoAb) against human uterine adenocarcinoma cell line SiSo, has been identified on various kinds of cancer cells. RCAS1 appears to be an apoptosis-associated protein that induces apoptosis in activated T-cells and erythroid progenitor cells. We previously demonstrated that monocytes/macrophages express RCAS1. In the present study, we investigated RCAS1 expression by 22-1-1 MoAb in histiocytic necrotizing lymphadenitis (HNL), which is characterized by necrotic lesions consisting of T-cells undergoing apoptosis and macrophages in proliferation. Expression of RCAS1 was analyzed by immunohistochemical staining in 9 cases of HNL and in 9 cases of reactive lymphadenitis used as a control. The ratio of RCAS1 + cells to CD68 + cells (monocytes/macrophages) was significantly higher in the patients with HNL than in the patients with reactive lymphadenitis (P=.0002;paired t test). Our findings suggest that RCAS1 expressed on macrophages may play an important role in the induction of activated T-cell apoptosis in cases of HNL.
AB - Receptor-binding cancer antigen expressed on SiSo cells (RCAS1), which is recognized by the 22-1-1 monoclonal antibody (MoAb) against human uterine adenocarcinoma cell line SiSo, has been identified on various kinds of cancer cells. RCAS1 appears to be an apoptosis-associated protein that induces apoptosis in activated T-cells and erythroid progenitor cells. We previously demonstrated that monocytes/macrophages express RCAS1. In the present study, we investigated RCAS1 expression by 22-1-1 MoAb in histiocytic necrotizing lymphadenitis (HNL), which is characterized by necrotic lesions consisting of T-cells undergoing apoptosis and macrophages in proliferation. Expression of RCAS1 was analyzed by immunohistochemical staining in 9 cases of HNL and in 9 cases of reactive lymphadenitis used as a control. The ratio of RCAS1 + cells to CD68 + cells (monocytes/macrophages) was significantly higher in the patients with HNL than in the patients with reactive lymphadenitis (P=.0002;paired t test). Our findings suggest that RCAS1 expressed on macrophages may play an important role in the induction of activated T-cell apoptosis in cases of HNL.
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U2 - 10.1007/BF02982644
DO - 10.1007/BF02982644
M3 - Article
C2 - 12774924
AN - SCOPUS:0141457896
SN - 0925-5710
VL - 77
SP - 359
EP - 363
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 4
ER -
