Abstract
Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.
| Original language | English |
|---|---|
| Pages (from-to) | 489-496 |
| Number of pages | 8 |
| Journal | Journal of Hepato-Biliary-Pancreatic Sciences |
| Volume | 23 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection. / Fujimoto, Takaaki; Ohtsuka, Takao; Date, Kenjiro; Kimura, Hideyo; Matsunaga, Taketo; Mori, Yasuhisa; Miyasaka, Yoshihiro; Mochidome, Naoki; Oda, Yoshinao; Nakamura, Masafumi.
In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 23, No. 8, 01.08.2016, p. 489-496.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection
AU - Fujimoto, Takaaki
AU - Ohtsuka, Takao
AU - Date, Kenjiro
AU - Kimura, Hideyo
AU - Matsunaga, Taketo
AU - Mori, Yasuhisa
AU - Miyasaka, Yoshihiro
AU - Mochidome, Naoki
AU - Oda, Yoshinao
AU - Nakamura, Masafumi
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.
AB - Background: An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. Methods: The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. Results: The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. Conclusions: BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.
UR - http://www.scopus.com/inward/record.url?scp=84982276392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982276392&partnerID=8YFLogxK
U2 - 10.1002/jhbp.367
DO - 10.1002/jhbp.367
M3 - Article
C2 - 27273680
AN - SCOPUS:84982276392
VL - 23
SP - 489
EP - 496
JO - Journal of Hepato-Biliary-Pancreatic Sciences
JF - Journal of Hepato-Biliary-Pancreatic Sciences
SN - 1868-6974
IS - 8
ER -