Expression of bcl-2-, p53, and Ki-67 and outcome of patients with primary nasopharyngeal carcinomas following DNA-damaging treatment

Muneyuki Masuda, Atushi Shinokuma, Naoya Hirakawa, Torahiko Nakashima, Sohtaro Komiyama

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Background: Recent studies suggest that apoptosis is important in the cell death induced by treatment that damages deoxyribonucleic acid (DNA). We assessed the correlation between the expression of the apoptosis-related proteins, p53 and bcl-2, and the clinical outcome of patients with nasopharyngeal carcinomas (NPCs) who were treated with both DNA-damaging treatments. We also assessed the level of Ki-67, a marker of cell proliferation, in these tumors. Methods: We evaluated statistically the relationships among the expression of p53, bcl-2, and Ki-67 and clinicopathologic factors, the sensitivity to radiation, the incidence of distant metastases, and survival. Results: The group that was positive for p53 tended to be resistant to radiotherapy and to have a significantly poorer prognosis (p = .05). Conclusions: The enhanced expression of p53 may be a prognostic factor in patients with NPCs whose tumor is resistant to therapy that damages DNA.

Original languageEnglish
Pages (from-to)640-644
Number of pages5
JournalHead and Neck
Volume20
Issue number7
DOIs
Publication statusPublished - Oct 1 1998

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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