Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma

Akira Haro, Tokujiro Yano, Mikihiro Kohno, Tsukihisa Yoshida, Takaomi Koga, Tatsuro Okamoto, Mitsuhiro Takenoyama, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Background. The clinical significance of Brachyury expression and its relationship to epithelial-mesenchymal transition in primary lung carcinoma is unclear. Methods. Expression of Brachyury mRNA was investigated in 104 surgically resected primary lung carcinoma tissues. Immunohistochemical analysis of Brachyury transcription factor, Slug, E-cadherin, IL-8, N-cadherin, and Ki67 was performed in 67 of 104 cases, and their expression was correlated to prognoses and clinicopathological factors. Results. Brachyury mRNA expression in primary lung carcinoma tissues was a significant predictor of poor prognosis for 5-year disease-free survival and overall survival rates and was significantly correlated to vascular invasion, lymphatic permeation, histological grade, pathologic T stage, and pathologic N stage (P\0.05). Brachyury mRNA expression was significantly inversely correlated to E-cadherin expression (P = 0.0252) and positively correlated to IL-8 protein (P = 0.0241) and to Slug protein (P = 0.0243) in adenocarcinoma tissues. Conclusions. A positive association between Brachyury and Slug and IL-8, and a negative association with E-cadherin may lead to invasiveness and metastasis in primary lung carcinoma. Brachyury mRNA expression is a significant predictor of poor prognosis in primary lung carcinoma.

Original languageEnglish
Pages (from-to)S509-S516
JournalAnnals of Surgical Oncology
Volume20
Issue number3 SUPPL.
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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