Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles

Hiroko Iwamasa, Kunimasa Ohta, Tomoko Yamada, Kazuo Ushijima, Hidenori Terasaki, Hideaki Tanaka

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Evidence is accumulating that Eph receptor tyrosine kinases and their ligands regulate cell migration and axonal guidance during development. It was previously found that one of the Eph receptors, EphA4, is transiently expressed in subsets of chick embryonic motor neurons. Here, the expression of EphA and ephrin- A subfamily members was further examined, and the dynamic patterns of expression in chick embryonic motor neurons found. EphA3, EphA4, ephrin-A2, and ephrin-A5 were also expressed in the connective tissues of limb muscles and EphA3 and EphA4 expressing motor neurons innervated EphA3 and EphA4 expressing limb muscles, respectively. These spatiotemporal expression patterns suggest that EphA and ephrin-A proteins play important roles in muscle patterning and motor axonal guidance.

Original languageEnglish
Pages (from-to)685-698
Number of pages14
JournalDevelopment Growth and Differentiation
Volume41
Issue number6
DOIs
Publication statusPublished - Dec 1 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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