Abstract
Summary. Acute megakaryoblastic leukaemia (M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers. To clarify properties of the blast cells in M7 and TMD cases, we examined erythroid markers expression in blasts from six cases with M7 and seven cases with TMD in this study. Erythroid‐specific mRNAs encoding 7‐globin and erythroid 6‐aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes. We also found that mRNAs encoding GATA‐1 and GATA‐2 are expressed in all these cases. These results suggest that M7 blasts and TMD blasts correspond to the erythroid/megakaryocytic bipotential progenitor cells.
| Original language | English |
|---|---|
| Pages (from-to) | 607-614 |
| Number of pages | 8 |
| Journal | British Journal of Haematology |
| Volume | 90 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1995 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Hematology
Cite this
Expression of erythroid‐specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome. / ITO, ETSURO; KASAI, MIKIO; HAYASHI, YASOHIDE; TOKI, TSUTOMU; ARAI, KOJI; YOKOYAMA, SHINKICHI; KATO, KOJI; TACHIBANA, NAOKI; YAMAMOTO, MASAYUKI; YOKOYAMA, MASARU.
In: British Journal of Haematology, Vol. 90, No. 3, 07.1995, p. 607-614.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of erythroid‐specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome
AU - ITO, ETSURO
AU - KASAI, MIKIO
AU - HAYASHI, YASOHIDE
AU - TOKI, TSUTOMU
AU - ARAI, KOJI
AU - YOKOYAMA, SHINKICHI
AU - KATO, KOJI
AU - TACHIBANA, NAOKI
AU - YAMAMOTO, MASAYUKI
AU - YOKOYAMA, MASARU
PY - 1995/7
Y1 - 1995/7
N2 - Summary. Acute megakaryoblastic leukaemia (M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers. To clarify properties of the blast cells in M7 and TMD cases, we examined erythroid markers expression in blasts from six cases with M7 and seven cases with TMD in this study. Erythroid‐specific mRNAs encoding 7‐globin and erythroid 6‐aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes. We also found that mRNAs encoding GATA‐1 and GATA‐2 are expressed in all these cases. These results suggest that M7 blasts and TMD blasts correspond to the erythroid/megakaryocytic bipotential progenitor cells.
AB - Summary. Acute megakaryoblastic leukaemia (M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers. To clarify properties of the blast cells in M7 and TMD cases, we examined erythroid markers expression in blasts from six cases with M7 and seven cases with TMD in this study. Erythroid‐specific mRNAs encoding 7‐globin and erythroid 6‐aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes. We also found that mRNAs encoding GATA‐1 and GATA‐2 are expressed in all these cases. These results suggest that M7 blasts and TMD blasts correspond to the erythroid/megakaryocytic bipotential progenitor cells.
UR - http://www.scopus.com/inward/record.url?scp=0029040851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029040851&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.1995.tb05591.x
DO - 10.1111/j.1365-2141.1995.tb05591.x
M3 - Article
C2 - 7647001
AN - SCOPUS:0029040851
VL - 90
SP - 607
EP - 614
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 3
ER -