TY - JOUR
T1 - Expression of granulysin in polymyositis and inclusion-body myositis
AU - Ikezoe, K.
AU - Ohshima, S.
AU - Osoegawa, M.
AU - Tanaka, M.
AU - Ogawa, K.
AU - Nagata, K.
AU - Kira, J. I.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/10
Y1 - 2006/10
N2 - Background: Granulysin, a recently defined cytolytic molecule, is expressed in cytotoxic T cells and natural killer cells in a similar way to perforin, which is reported to have a major role in the pathogenesis of polymyositis and inclusion-body myositis (IBM). Objective: To clarify the role of granulysin in polymyositis and IBM. Methods: The expression of granulysin and perform was examined by double staining with CD8, CD4 and CD56 in endomysial infiltrating cells and autoinvasive cells in muscle biopsy specimens of 17 patients with polymyositis (6 steroid resistant and 11 steroid responsive) and of 7 patients with IBM. Results: Similar to perform, granulysin was expressed in CD8, CD4 or CD56 cells in patients with polymyositis and IBM. The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Conclusion: Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis.
AB - Background: Granulysin, a recently defined cytolytic molecule, is expressed in cytotoxic T cells and natural killer cells in a similar way to perforin, which is reported to have a major role in the pathogenesis of polymyositis and inclusion-body myositis (IBM). Objective: To clarify the role of granulysin in polymyositis and IBM. Methods: The expression of granulysin and perform was examined by double staining with CD8, CD4 and CD56 in endomysial infiltrating cells and autoinvasive cells in muscle biopsy specimens of 17 patients with polymyositis (6 steroid resistant and 11 steroid responsive) and of 7 patients with IBM. Results: Similar to perform, granulysin was expressed in CD8, CD4 or CD56 cells in patients with polymyositis and IBM. The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Conclusion: Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis.
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U2 - 10.1136/jnnp.2005.081810
DO - 10.1136/jnnp.2005.081810
M3 - Article
C2 - 16980658
AN - SCOPUS:33749020859
SN - 0022-3050
VL - 77
SP - 1187
EP - 1190
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 10
ER -
