Expression of granulysin in polymyositis and inclusion-body myositis

K. Ikezoe, S. Ohshima, M. Osoegawa, M. Tanaka, K. Ogawa, K. Nagata, Jun-Ichi Kira

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Granulysin, a recently defined cytolytic molecule, is expressed in cytotoxic T cells and natural killer cells in a similar way to perforin, which is reported to have a major role in the pathogenesis of polymyositis and inclusion-body myositis (IBM). Objective: To clarify the role of granulysin in polymyositis and IBM. Methods: The expression of granulysin and perform was examined by double staining with CD8, CD4 and CD56 in endomysial infiltrating cells and autoinvasive cells in muscle biopsy specimens of 17 patients with polymyositis (6 steroid resistant and 11 steroid responsive) and of 7 patients with IBM. Results: Similar to perform, granulysin was expressed in CD8, CD4 or CD56 cells in patients with polymyositis and IBM. The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Conclusion: Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis.

Original languageEnglish
Pages (from-to)1187-1190
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume77
Issue number10
DOIs
Publication statusPublished - Oct 1 2006

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Inclusion Body Myositis
Polymyositis
Steroids
Perforin
Natural Killer Cells
Muscle Cells
Staining and Labeling
T-Lymphocytes
Biopsy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Expression of granulysin in polymyositis and inclusion-body myositis. / Ikezoe, K.; Ohshima, S.; Osoegawa, M.; Tanaka, M.; Ogawa, K.; Nagata, K.; Kira, Jun-Ichi.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 77, No. 10, 01.10.2006, p. 1187-1190.

Research output: Contribution to journalArticle

Ikezoe, K. ; Ohshima, S. ; Osoegawa, M. ; Tanaka, M. ; Ogawa, K. ; Nagata, K. ; Kira, Jun-Ichi. / Expression of granulysin in polymyositis and inclusion-body myositis. In: Journal of Neurology, Neurosurgery and Psychiatry. 2006 ; Vol. 77, No. 10. pp. 1187-1190.
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