Expression of hMTHI in the hippocampi of control and Alzheimer's disease

Akiko Furuta, Takashi Iida, Yusaku Nakabeppu, Toru Iwaki

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The oxidized purine nucleoside triphosphatase, hMTHI, has a critical role towards preventing errors caused by oxidized purine nucleoside triphosphates such as 8-oxo-dGTP and 2-hydroxy-dATP. We investigated the immunohistochemical expression of hMTHI in human hippocampal postmortem tissues representing non-neurological disease and Alzheimer's disease (AD). In the non-neurological subjects the hMTHI protein was enriched in the stratum lucidum at CA3 corresponding to mossy fiber synapses. In AD subjects, the synaptic immunoreactivities at CA3 were significantly decreased, whereas they tended to be increased at the entorhinal cortex. We suggest that the expression of hMTHI indicates indirect evidence of oxidative stress and its regulation is regionally differentiated in AD.

Original languageEnglish
Pages (from-to)2895-2899
Number of pages5
JournalNeuroReport
Volume12
Issue number13
DOIs
Publication statusPublished - Sep 17 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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