Expression of hypoxia-inducible factor-1α, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: Correlation with poor prognosis with possible regulation

Kotaro Miyake, Tomoharu Yoshizumi, Satoru Imura, Koji Sugimoto, Erdenebulgan Batmunkh, Hirofumi Kanemura, Yuji Morine, Mitsuo Shimada

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

OBJECTIVES: Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays an important role in tumor growth and metastasis. Inhibition of histone deacetylase shows a marked inhibition of HIF-1α expression; however, the association between HIF-1α and histone deacetylase 1 (HDAC1), metastasis-associated protein 1 (MTA1) is not fully understood. METHODS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 expressions were detected by immunohistochemistry in 39 pancreatic carcinoma patients. The correlations between the expression of HIF-1α, HDAC1, or MTA1 and clinical features and the prognosis were analyzed. RESULTS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 positive stainings were found in 41%, 56%, and 31%, respectively. There was no correlation between HIF-1α, HDAC1, or MTA1 expression levels and any clinical parameters. The survival rate for patients with HIF-1α and HDAC1-positive stainings were significantly lower than for patients with HIF-1α and HDAC1-negative stainings. The MTA1 overexpression group did not have a significantly lower prognosis than the MTA1 underexpression group. The survival rate for the HDAC1(+)/MTA1(2-3) group was significantly lower than for the other groups. CONCLUSIONS: These results suggest that HIF-1α expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma and indicates that HIF-1α and HDAC1/MTA1 are a promising therapeutic target in pancreatic carcinoma treatment.

Original languageEnglish
Pages (from-to)e1-e9
JournalPancreas
Volume36
Issue number3
DOIs
Publication statusPublished - Apr 1 2008

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Histone Deacetylase 1
Hypoxia-Inducible Factor 1
Neoplasm Metastasis
Proteins
Pancreatic Carcinoma
Survival Rate
Staining and Labeling
Negative Staining
Histone Deacetylases

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Expression of hypoxia-inducible factor-1α, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma : Correlation with poor prognosis with possible regulation. / Miyake, Kotaro; Yoshizumi, Tomoharu; Imura, Satoru; Sugimoto, Koji; Batmunkh, Erdenebulgan; Kanemura, Hirofumi; Morine, Yuji; Shimada, Mitsuo.

In: Pancreas, Vol. 36, No. 3, 01.04.2008, p. e1-e9.

Research output: Contribution to journalArticle

Miyake, Kotaro ; Yoshizumi, Tomoharu ; Imura, Satoru ; Sugimoto, Koji ; Batmunkh, Erdenebulgan ; Kanemura, Hirofumi ; Morine, Yuji ; Shimada, Mitsuo. / Expression of hypoxia-inducible factor-1α, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma : Correlation with poor prognosis with possible regulation. In: Pancreas. 2008 ; Vol. 36, No. 3. pp. e1-e9.
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abstract = "OBJECTIVES: Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays an important role in tumor growth and metastasis. Inhibition of histone deacetylase shows a marked inhibition of HIF-1α expression; however, the association between HIF-1α and histone deacetylase 1 (HDAC1), metastasis-associated protein 1 (MTA1) is not fully understood. METHODS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 expressions were detected by immunohistochemistry in 39 pancreatic carcinoma patients. The correlations between the expression of HIF-1α, HDAC1, or MTA1 and clinical features and the prognosis were analyzed. RESULTS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 positive stainings were found in 41{\%}, 56{\%}, and 31{\%}, respectively. There was no correlation between HIF-1α, HDAC1, or MTA1 expression levels and any clinical parameters. The survival rate for patients with HIF-1α and HDAC1-positive stainings were significantly lower than for patients with HIF-1α and HDAC1-negative stainings. The MTA1 overexpression group did not have a significantly lower prognosis than the MTA1 underexpression group. The survival rate for the HDAC1(+)/MTA1(2-3) group was significantly lower than for the other groups. CONCLUSIONS: These results suggest that HIF-1α expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma and indicates that HIF-1α and HDAC1/MTA1 are a promising therapeutic target in pancreatic carcinoma treatment.",
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T1 - Expression of hypoxia-inducible factor-1α, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma

T2 - Correlation with poor prognosis with possible regulation

AU - Miyake, Kotaro

AU - Yoshizumi, Tomoharu

AU - Imura, Satoru

AU - Sugimoto, Koji

AU - Batmunkh, Erdenebulgan

AU - Kanemura, Hirofumi

AU - Morine, Yuji

AU - Shimada, Mitsuo

PY - 2008/4/1

Y1 - 2008/4/1

N2 - OBJECTIVES: Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays an important role in tumor growth and metastasis. Inhibition of histone deacetylase shows a marked inhibition of HIF-1α expression; however, the association between HIF-1α and histone deacetylase 1 (HDAC1), metastasis-associated protein 1 (MTA1) is not fully understood. METHODS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 expressions were detected by immunohistochemistry in 39 pancreatic carcinoma patients. The correlations between the expression of HIF-1α, HDAC1, or MTA1 and clinical features and the prognosis were analyzed. RESULTS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 positive stainings were found in 41%, 56%, and 31%, respectively. There was no correlation between HIF-1α, HDAC1, or MTA1 expression levels and any clinical parameters. The survival rate for patients with HIF-1α and HDAC1-positive stainings were significantly lower than for patients with HIF-1α and HDAC1-negative stainings. The MTA1 overexpression group did not have a significantly lower prognosis than the MTA1 underexpression group. The survival rate for the HDAC1(+)/MTA1(2-3) group was significantly lower than for the other groups. CONCLUSIONS: These results suggest that HIF-1α expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma and indicates that HIF-1α and HDAC1/MTA1 are a promising therapeutic target in pancreatic carcinoma treatment.

AB - OBJECTIVES: Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays an important role in tumor growth and metastasis. Inhibition of histone deacetylase shows a marked inhibition of HIF-1α expression; however, the association between HIF-1α and histone deacetylase 1 (HDAC1), metastasis-associated protein 1 (MTA1) is not fully understood. METHODS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 expressions were detected by immunohistochemistry in 39 pancreatic carcinoma patients. The correlations between the expression of HIF-1α, HDAC1, or MTA1 and clinical features and the prognosis were analyzed. RESULTS: Hypoxia-inducible factor 1α, HDAC1, and MTA1 positive stainings were found in 41%, 56%, and 31%, respectively. There was no correlation between HIF-1α, HDAC1, or MTA1 expression levels and any clinical parameters. The survival rate for patients with HIF-1α and HDAC1-positive stainings were significantly lower than for patients with HIF-1α and HDAC1-negative stainings. The MTA1 overexpression group did not have a significantly lower prognosis than the MTA1 underexpression group. The survival rate for the HDAC1(+)/MTA1(2-3) group was significantly lower than for the other groups. CONCLUSIONS: These results suggest that HIF-1α expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma and indicates that HIF-1α and HDAC1/MTA1 are a promising therapeutic target in pancreatic carcinoma treatment.

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