Expression of integrins in squamous cell carcinoma of the oral cavity: Correlations with tumor invasion and metastasis

Masanori Shinohara, Seiji Nakamura, Masanori Sasaki, Shinichi Kurahara, Tetsuro Ikebe, Takeshi Harada, Kanemitsu Shirasuna

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33 Citations (Scopus)


Integrins are cell adhesion molecules that mediate the cell to extracellular matrix interactions. We sought to determine whether the integrin expression on tumor cells is associated with invasive and metastatic potential. First, in 8 cell lines of oral squamous cell carcinoma, 4 of which were metastatic in nude mice and 4 of which were not, integrin expression was examined. When these cell lines were cultured in vitro or transplanted into the tongues of nude mice, the metastatic cell lines tended to show a stronger expression of α2, α3, α5, and α6 integrins than did the nonmetastatic cell lines. Second, integrin expression was immunohistochemically examined in 65 biopsy specimens of primary oral squamous cell carcinoma. In invasive or metastatic cases, a marked expression of α2, α3, α5, and α6 integrins was frequently observed. The association of integrin expression with the mode of tumor invasion and nodal involvement was found to be statistically significant. These results suggest that integrin expression is closely associated with tumor invasion and nodal involvement in oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)75-88
Number of pages14
JournalAmerican Journal of Clinical Pathology
Issue number1
Publication statusPublished - Jan 1 1999


All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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