Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor

Tsuyoshi Saito, Yoshinao Oda, Eijun Itakura, Hideki Shiratsuchi, Yoshiaki Kinoshita, Yumi Oshiro, Sadafumi Tamiya, Yoichi Hachitanda, Yukihide Iwamoto, Masazumi Tsuneyoshi

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Abstract

We clinicopathologically evaluated 31 cases of epithelioid sarcoma (ES; 25 'classical' type and six 'proximal variant' type) and six cases of malignant rhabdoid tumor (MRT; three extrarenal and three renal). We also did immunohistochemical studies on 12 classical and three proximal variant cases of ES, and six cases of MRT, to clarify the differences in biological behavior in these tumors. E-cadherin, β-catenin and CD34 expression was evaluated. We also carried out mutational analysis of exon 3 of the β-catenin gene by polymerase chain reaction-single-strand conformation polymorphism analysis. In ES, the 5- and 10-year survival rates were 71.1 and 55.3%, respectively. A high mitotic rate (>15/10 high-power fields) was significantly correlated with a poor overall survival rate in ES (P = 0.0248). E-cadherin expression was observed in nine cases (69.2%) of ES and in four cases (66.7%) of MRT. Most of these tumors showed aberrant E-cadherin expression. Seven cases (46.7%) of ES were positive for CD34, although none of the cases of MRT were CD34 positive. Eleven cases (73.3%) of ES were positive for β-catenin, which was localized to the cellular membrane, whereas all of the cases of MRT were β-catenin negative. Mutational analysis for the β-catenin gene was done in nine cases of ES and six cases of MRT, however, genetic alteration was not found. From our results, we conclude that β-catenin membranous expression could be a useful marker for distinguishing ES, including the proximal variant, from MRT.

Original languageEnglish
Pages (from-to)532-542
Number of pages11
JournalPathology International
Volume51
Issue number7
DOIs
Publication statusPublished - Aug 23 2001

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Rhabdoid Tumor
Catenins
Cell Adhesion Molecules
Sarcoma
Cadherins
Genes
Exons
Neoplasms
Kidney
Polymerase Chain Reaction
Membranes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor. / Saito, Tsuyoshi; Oda, Yoshinao; Itakura, Eijun; Shiratsuchi, Hideki; Kinoshita, Yoshiaki; Oshiro, Yumi; Tamiya, Sadafumi; Hachitanda, Yoichi; Iwamoto, Yukihide; Tsuneyoshi, Masazumi.

In: Pathology International, Vol. 51, No. 7, 23.08.2001, p. 532-542.

Research output: Contribution to journalArticle

Saito, T, Oda, Y, Itakura, E, Shiratsuchi, H, Kinoshita, Y, Oshiro, Y, Tamiya, S, Hachitanda, Y, Iwamoto, Y & Tsuneyoshi, M 2001, 'Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor', Pathology International, vol. 51, no. 7, pp. 532-542. https://doi.org/10.1046/j.1440-1827.2001.01232.x
Saito, Tsuyoshi ; Oda, Yoshinao ; Itakura, Eijun ; Shiratsuchi, Hideki ; Kinoshita, Yoshiaki ; Oshiro, Yumi ; Tamiya, Sadafumi ; Hachitanda, Yoichi ; Iwamoto, Yukihide ; Tsuneyoshi, Masazumi. / Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor. In: Pathology International. 2001 ; Vol. 51, No. 7. pp. 532-542.
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AU - Kinoshita, Yoshiaki

AU - Oshiro, Yumi

AU - Tamiya, Sadafumi

AU - Hachitanda, Yoichi

AU - Iwamoto, Yukihide

AU - Tsuneyoshi, Masazumi

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