Expression of interferon alpha/beta receptor in human hepatocellular carcinoma.

M. Kondo, H. Nagano, M. Sakon, H. Yamamoto, O. Morimoto, I. Arai, A. Miyamoto, H. Eguchi, K. Dono, S. Nakamori, K. Umeshita, K. Wakasa, Y. Ohmoto, M. Monden

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Abstract

Interferon-alpha (IFNalpha) plays a crucial role in the antiproliferation and immunoregulatory activity through the specific cell surface receptor, interferon-alpha/beta receptor (IFNalpha/betaR). We examined the immunohistochemical expression of IFNalpha/betaR in 91 hepatocellular carcinoma (HCC), HCV-related chronic hepatitis (n=38) and cirrhosis (n=53), dysplastic nodules (n=5), and normal liver (n=9). The level of IFNalpha/betaR increased in chronic hepatitis and cirrhosis compared with normal liver. All the dysplastic nodules showed moderate or high expression. In HCCs, 26% (24/91) of patients showed high IFNalpha/betaR expression while the remaining 38% (35/91) showed moderate, and 35% (32/91) no or faint expression. Clinicopathological survey demonstrated a significant correlation between IFNalpha/betaR expression and differentiation of carcinoma (P=0.0008) although there was no correlation between IFNalpha/betaR expression in HCC and survival or disease-free survival. Thus, IFNalpha/betaR was expressed not only in chronic hepatitis or liver cirrhosis but in HCC and its expression was significantly correlated with tissue differentiation of carcinoma.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalInternational journal of oncology
Volume17
Issue number1
DOIs
Publication statusPublished - Jul 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kondo, M., Nagano, H., Sakon, M., Yamamoto, H., Morimoto, O., Arai, I., Miyamoto, A., Eguchi, H., Dono, K., Nakamori, S., Umeshita, K., Wakasa, K., Ohmoto, Y., & Monden, M. (2000). Expression of interferon alpha/beta receptor in human hepatocellular carcinoma. International journal of oncology, 17(1), 83-88. https://doi.org/10.3892/ijo.17.1.83