Expression of long-term potentiation of the striatum in methamphetamine- sensitized rats

Tsuyoshi Nishioku, Takao Shimazoe, Yasuharu Yamamoto, Hiroshi Nakanishi, Shigenori Watanabe

Research output: Contribution to journalArticle

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Abstract

We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the field potential in the striatum of saline-treated rats. However, it induced long- term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was significantly suppressed by a N-methyl-D-aspartate (NMDA) receptor antagonist, aminophosphono-valeric acid (APV). These results suggest that LTP is expressed in the striatum of MAP-sensitized rats, and that NMDA receptors are indispensable for the LTP formation.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume268
Issue number2
DOIs
Publication statusPublished - Jun 18 1999

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Methamphetamine
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Corpus Striatum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Expression of long-term potentiation of the striatum in methamphetamine- sensitized rats. / Nishioku, Tsuyoshi; Shimazoe, Takao; Yamamoto, Yasuharu; Nakanishi, Hiroshi; Watanabe, Shigenori.

In: Neuroscience Letters, Vol. 268, No. 2, 18.06.1999, p. 81-84.

Research output: Contribution to journalArticle

Nishioku, Tsuyoshi ; Shimazoe, Takao ; Yamamoto, Yasuharu ; Nakanishi, Hiroshi ; Watanabe, Shigenori. / Expression of long-term potentiation of the striatum in methamphetamine- sensitized rats. In: Neuroscience Letters. 1999 ; Vol. 268, No. 2. pp. 81-84.
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