TY - JOUR
T1 - Expression of long-term potentiation of the striatum in methamphetamine- sensitized rats
AU - Nishioku, Tsuyoshi
AU - Shimazoe, Takao
AU - Yamamoto, Yasuharu
AU - Nakanishi, Hiroshi
AU - Watanabe, Shigenori
PY - 1999/6/18
Y1 - 1999/6/18
N2 - We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the field potential in the striatum of saline-treated rats. However, it induced long- term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was significantly suppressed by a N-methyl-D-aspartate (NMDA) receptor antagonist, aminophosphono-valeric acid (APV). These results suggest that LTP is expressed in the striatum of MAP-sensitized rats, and that NMDA receptors are indispensable for the LTP formation.
AB - We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the field potential in the striatum of saline-treated rats. However, it induced long- term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was significantly suppressed by a N-methyl-D-aspartate (NMDA) receptor antagonist, aminophosphono-valeric acid (APV). These results suggest that LTP is expressed in the striatum of MAP-sensitized rats, and that NMDA receptors are indispensable for the LTP formation.
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U2 - 10.1016/S0304-3940(99)00386-9
DO - 10.1016/S0304-3940(99)00386-9
M3 - Article
C2 - 10400083
AN - SCOPUS:0033580978
SN - 0304-3940
VL - 268
SP - 81
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -