Expression of long-term potentiation of the striatum in methamphetamine- sensitized rats

Tsuyoshi Nishioku, Takao Shimazoe, Yasuharu Yamamoto, Hiroshi Nakanishi, Shigenori Watanabe

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the field potential in the striatum of saline-treated rats. However, it induced long- term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was significantly suppressed by a N-methyl-D-aspartate (NMDA) receptor antagonist, aminophosphono-valeric acid (APV). These results suggest that LTP is expressed in the striatum of MAP-sensitized rats, and that NMDA receptors are indispensable for the LTP formation.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume268
Issue number2
DOIs
Publication statusPublished - Jun 18 1999

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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