Expression of mRNA for activin-binding protein (follistatin) during early embryonic development of Xenopus laevis

Kosuke Tashiro, Ryutaro Yamada, Misaki Asano, Makoto Hashimoto, Masami Muramatsu, Koichiro Shiokawa

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Follistatin is a specific activin-binding protein and is supposed to control activin functions. During Xenopus embryonic development, activin is thought to act as a natural mesoderm-inducing factor. We isolated here the Xenopus follistatin cDNA from Xenopus ovary cDNA library and studied the expression of Xenopus follistatin gene during the course of early embryonic development. The Xenopus follistatin has an 84 % homology at the level of deduced amino acid sequence with human and porcine follistatin. Its 3.5 kb mRNA is first expressed at the gastrula stage, when the expression of activin mRNA becomes first detectable, and increased thereafter. Another species of 2 kb mRNA become detectable from early neurula and also increased dramatically in tadpole. These results suggest that the follistatin acts also as a regulator of activin in inductive interactions during amphibian embryonic development.

Original languageEnglish
Pages (from-to)1022-1027
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume174
Issue number2
DOIs
Publication statusPublished - Jan 31 1991
Externally publishedYes

Fingerprint

Follistatin
Xenopus laevis
Embryonic Development
Xenopus
Activins
Messenger RNA
Gastrula
Amphibians
Mesoderm
Gene Library
Larva
Amino Acid Sequence
Ovary
Swine
Complementary DNA
Genes
Amino Acids

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Expression of mRNA for activin-binding protein (follistatin) during early embryonic development of Xenopus laevis. / Tashiro, Kosuke; Yamada, Ryutaro; Asano, Misaki; Hashimoto, Makoto; Muramatsu, Masami; Shiokawa, Koichiro.

In: Biochemical and Biophysical Research Communications, Vol. 174, No. 2, 31.01.1991, p. 1022-1027.

Research output: Contribution to journalArticle

Tashiro, Kosuke ; Yamada, Ryutaro ; Asano, Misaki ; Hashimoto, Makoto ; Muramatsu, Masami ; Shiokawa, Koichiro. / Expression of mRNA for activin-binding protein (follistatin) during early embryonic development of Xenopus laevis. In: Biochemical and Biophysical Research Communications. 1991 ; Vol. 174, No. 2. pp. 1022-1027.
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