Expression of multidrug resistance-associated protein gene in Ewing's sarcoma and malignant peripheral neuroectodermal tumor of bone

Yoshinao Oda, Barbara Dockhorn-Dworniczak, Herbert Jürgens, Albert Roessner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The expression of multidrug resistance-associated protein (MRP) mRNA was examined in ten samples of Ewing's sarcoma of bone (ES) and in one nude mice transplantable ES and two malignant peripheral neuroectodermal tumor (MPNT) cell lines using an RT-PCR assay. MRP mRNA expression was recognized in eight of the ten clinical specimen and in all three cell lines. On the other hand, the expression of multidrug resistance gene (MDR1) was demonstrated in three of the ten clinical samples and all three cell lines. Our results may contribute to elucidation of the mechanism of anti-cancer-drug resistance in this tumor.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
JournalJournal of Cancer Research and Clinical Oncology
Volume123
Issue number4
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

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Peripheral Primitive Neuroectodermal Tumors
Multidrug Resistance-Associated Proteins
Ewing's Sarcoma
MDR Genes
Bone and Bones
Cell Line
Messenger RNA
Tumor Cell Line
Drug Resistance
Nude Mice
Genes
Neoplasms
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Expression of multidrug resistance-associated protein gene in Ewing's sarcoma and malignant peripheral neuroectodermal tumor of bone. / Oda, Yoshinao; Dockhorn-Dworniczak, Barbara; Jürgens, Herbert; Roessner, Albert.

In: Journal of Cancer Research and Clinical Oncology, Vol. 123, No. 4, 01.01.1997, p. 237-239.

Research output: Contribution to journalArticle

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