Expression of multidrug-resistance-associated protein gene in human soft-tissue sarcomas

Yoshinao Oda, Regine Schneider-Stock, Janusz Ryś, Andrzej Gruchala, Aleksander Niezabitowski, Albert Roessner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We examined the mRNA expression of the multidrug-resistance-associated protein gene (MRP) in soft-tissue sarcomas and compared it with the expression of the multidrug resistance gene (MDR1), using the reverse transcriptase/polymerase chain reaction. We investigated 39 samples from 33 cases of soft-tissue sarcomas (11 liposarcomas, 9 malignant fibrous histiocytomas, 6 leiomyosarcomas, 4 malignant schwannomas, 3 fibrosarcomas, 3 synovial sarcomas, and 3 epithelioid sarcomas) and 7 benign soft-tissue tumors. All samples were obtained prior to chemotherapy. An expression of MRP mRNA was noted in 56% of soft-tissue sarcoma specimens. The co-expression of MRP and MDR1 was recognized in 15 samples (38%) (5/11 liposarcomas, 5/9 malignant fibrous histiocytomas, 3/6 leiomyosarcomas, 2/3 fibrosarcomas) and significantly correlated with histological grade (P = 0.0165). A positive and significant correlation was found between MRP and MDR1 expression in soft-tissue sarcomas (P = 0.0013). In benign soft-tissue tumors, 1 chemodectoma and 1 neurothekeoma showed low MRP expression; however, no case showed co-expression of MRP and MDR1.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalJournal of Cancer Research and Clinical Oncology
Volume122
Issue number3
DOIs
Publication statusPublished - Feb 23 1996
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this