Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours

Koshi Mimori, Masaki Mori, Takeshi Shiraishi, Shinji Tanaka, Masaru Haraguchi, Hiroaki Ueo, Chiaki Shirasaka, Tsuyoshi Akiyoshi

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Abstract

We examined the expression of ornithine decarboxylase (ODC) mRNA in 53 female cases of breast cancer by a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to determine the clinicopathologic significance of its expression. A significantly higher expression of ODC mRNA was, observed in younger patients than in older patients. The patients with a larger sized tumour possessed a significantly higher expression of ODC mRNA. In addition, the cases with a poor prognosis showed significantly higher expression of ODC. Previous studies have reported in vivo and in vitro correlation between the expression of ODC and c-myc genes in human carcinomas. We disclosed a significant correlation between these genes in primary breast carcinomas. We conclude that the expression of ODC may potentially be a new biological marker for breast carcinoma.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalInternational journal of oncology
Volume12
Issue number3
Publication statusPublished - Mar 1 1998

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Mimori, K., Mori, M., Shiraishi, T., Tanaka, S., Haraguchi, M., Ueo, H., ... Akiyoshi, T. (1998). Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours. International journal of oncology, 12(3), 597-601.