Expression of p53 and p21 and the clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus

Mayumi Ishida, Masaru Morita, Hiroshi Saeki, Takefumi Ohga, Noriaki Sadanaga, Masayuki Watanabe, Yoshihiro Kakeji, Yoshihiko Maehara

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15 Citations (Scopus)

Abstract

Background: The p53 and p21 genes are closely related to sensitivity to chemoradiotherapy. Patients and Methods: The expressions of the p53 and p21 genes were immunohistochemically examined in 32 patients with esophageal cancer, who underwent an esophagectomy after hyperthermochemoradiotherapy (HCRT). The significance of the expression of these genes for the effect of HCRT was evaluated. Results: HCRT was markedly effective (grade 3 response: no residual viable cancer cells) in 12 cases (38%). The incidences of the grade 3 were 67% and 20% in the cases with a positive and negative p21 expression, respectively (p=0.0213). A multivariate analysis revealed the p21 expression to be a significant independent factor associated with the histological effects. None of the 10 patients with p53-positive and p21-negative tumors showed a grade 3 response, while 55% showed grade 3 response in other combination groups (p<0.05). Conclusion: The combination of p53 and p21 expressions in biopsy findings can thus predict the histological effectiveness of HCRT.

Original languageEnglish
Pages (from-to)3501-3506
Number of pages6
JournalAnticancer research
Volume27
Issue number5 B
Publication statusPublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Ishida, M., Morita, M., Saeki, H., Ohga, T., Sadanaga, N., Watanabe, M., Kakeji, Y., & Maehara, Y. (2007). Expression of p53 and p21 and the clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus. Anticancer research, 27(5 B), 3501-3506.