Expression of phosphorylated Stat3, cyclin D1 and Bcl-xL in extramammary Paget disease

H. J. Liu, Y. Moroi, T. Masuda, S. Yasumoto, H. Kokuba, S. Imafuku, T. Koga, T. Tetsuya, Y. T. Tu, H. Aburatani, M. Furue, K. Urabe

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Abstract

Background: Stat3 (Signal transducer and activator of transcription-3) is an oncogene that plays a critical role in regulating fundamental processes associated with malignant transformation and cell survival. It participates in oncogenesis through upregulation of genes encoding apoptosis inhibitors (Bcl-xL) and cell cycle regulators (cyclin D1). The expression of Stat3, Bcl-xL and cyclin D1 protein has not been investigated in extramammary Paget disease (EMPD). Objectives: To study the expression of phosphorylated Stat3 (p-Stat3), Bcl-xL and cyclin D1 protein in EMPD and to evaluate the relationships among them. Methods: Thirty-six tissue samples from 34 patients with primary EMPD were subjected to immunohistochemical staining for p-Stat3, cyclin D1 and Bcl-xL. Results: Thirty-five of 36 specimens were clearly positive for p-Stat3 in EMPD, while 30 of 36 and 32 of 36 were positive for cyclin D1 and Bcl-xL expression, respectively. In all of four invasive EMPD specimens, strong and frequent expression of these three molecules was evident; moreover, two invasive EMPD specimens with lymph nodal metastasis showed very strong nuclear and membranous p-Stat3 staining. Two metastatic lymph node specimens showed very strong nuclear and local membrane p-Stat3 staining. There were significant correlations between p-Stat3 and cyclin D1 expression and between p-Stat3 and Bcl-xL expression. Conclusions: Our study shows that the expression of p-Stat3, cyclin D 1 and Bcl-xL may play a pivotal role in the pathogenesis of EMPD.

Original languageEnglish
Pages (from-to)926-932
Number of pages7
JournalBritish Journal of Dermatology
Volume154
Issue number5
DOIs
Publication statusPublished - May 1 2006

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Liu, H. J., Moroi, Y., Masuda, T., Yasumoto, S., Kokuba, H., Imafuku, S., Koga, T., Tetsuya, T., Tu, Y. T., Aburatani, H., Furue, M., & Urabe, K. (2006). Expression of phosphorylated Stat3, cyclin D1 and Bcl-xL in extramammary Paget disease. British Journal of Dermatology, 154(5), 926-932. https://doi.org/10.1111/j.1365-2133.2005.06951.x