Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud

Koji Tamura, Takanori Amano, Taeko Satoh, Daisuke Saito, Sayuri Yonei-Tamura, Hiroshi Yajima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In a differential display screening for genes regulated by retinoic acid in the developing chick limb bud, we have isolated a novel gene, termed rigf, retinoic-acid induced growth factor, that encodes a protein belonging to the vascular endothelial growth factor (VEGF) family. Rigf transcripts were found in the posterior region of the limb bud in a region-specific manner as well as in other embryonic tissues and regions, including the notochord, head and trunk mesenchyme, retinal pigment epithelium, and branchial arches. Several manipulations revealed that retinoic acid and sonic hedgehog signaling pathways regulate rigf expression in the limb bud. VEGF family members, which promote the migration, differentiation and proliferation of endothelial cells in both blood and lymphatic vessels, are important factors for the formation of blood and lymphatic vasculatures during development. We demonstrated that the anterior border of the rigf expression domain in the limb bud corresponds with the position of the primary central artery (the subclavian artery in the forelimb), which is a main artery for supplying blood to the limb. These observations taken together with results from some experimental manipulations suggest that the limb tissue attracts blood vessels into the limb bud and that rigf is involved in the pattern formation of blood vessels in the limb.

Original languageEnglish
Pages (from-to)199-209
Number of pages11
JournalMechanisms of Development
Volume120
Issue number2
DOIs
Publication statusPublished - Jan 1 2003
Externally publishedYes

Fingerprint

Limb Buds
Vascular Endothelial Growth Factor A
Blood Vessels
Tretinoin
Extremities
Arteries
Branchial Region
Notochord
Lymphatic Vessels
Subclavian Artery
Forelimb
Retinal Pigment Epithelium
Mesoderm
Genes
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Head
Proteins

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

Cite this

Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. / Tamura, Koji; Amano, Takanori; Satoh, Taeko; Saito, Daisuke; Yonei-Tamura, Sayuri; Yajima, Hiroshi.

In: Mechanisms of Development, Vol. 120, No. 2, 01.01.2003, p. 199-209.

Research output: Contribution to journalArticle

Tamura, Koji ; Amano, Takanori ; Satoh, Taeko ; Saito, Daisuke ; Yonei-Tamura, Sayuri ; Yajima, Hiroshi. / Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. In: Mechanisms of Development. 2003 ; Vol. 120, No. 2. pp. 199-209.
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