Expression of Sialyl-Tn Antigens in Normal Squamous Epithelium, Dysplasia, and Squamous Cell Carcinoma in the Esophagus

Yoichi Ikeda, Hiroyuki Kuwano, Kinya Baba, Masahiko Ikebe, Tetuya Matushima, Yousuke Adachi, Masaki Mori, Keizo Sugimachi

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Abstract

Two monoclonal antibodies, TKH2 and B723, directed toward the Sialyl-Tn antigen (SA 2,6GalNAcα-0-Ser/Thr), were examined immuno-histochemically to analyze the expression of these antigens in 20 areas of normal squamous epithelium, 12 lesions of dysplasia, and 86 cases of squamous cell carcinoma including 32 with superficial carcinoma in the esophagus. No expression of TKH2 or B72 J was found in the normal squamous epithelium. Among the 12 lesions of dysplasia only one ex-pressed TKH2. In carcinoma the expression of TKH2 and B72.3 was found in 40 (47%) and 21 (24%) of the 86 carcinomas, respectively; however, the number of positive malignant cells with TKH2 and B723 totaled less than half that in the tissue, and no relationship was found between either prognosis or lymph node metastasis and the expression of Sialyl-Tn antigen. These results indicate that Sialyl-Tn antigen appears in the process of malignant transformation or tumor progression in esophageal squamous cell carcinoma; however, the positive expression of Sialyl-Tn antigen was not directly connected to either prognosis or lymph node metastasis.

Original languageEnglish
Pages (from-to)1706-1708
Number of pages3
JournalCancer Research
Volume53
Issue number7
Publication statusPublished - Apr 1993

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ikeda, Y., Kuwano, H., Baba, K., Ikebe, M., Matushima, T., Adachi, Y., ... Sugimachi, K. (1993). Expression of Sialyl-Tn Antigens in Normal Squamous Epithelium, Dysplasia, and Squamous Cell Carcinoma in the Esophagus. Cancer Research, 53(7), 1706-1708.