Expression of T cell receptor Vγ5 in the adult thymus of irradiated mice after transplantation with fetal liver cells

Masaro Ogimoto, Yasunobu Yoshikai, Goro Matsuzaki, Koji Matsumoto, Kenji Kishihara, Kikuo Nomoto

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    T cell receptor (TcR) γ/δ displays limited diversity and its diversity is distinct in different stages of ontogeny and in different anatomical sites. The Vγ5 and Vδ1 gene products are preferentially expressed on the early fetal thymocytes and on Thy‐1+ dendritic epidermal cells, whereas the Vγ4 and Vδ5 gene products are abundantly expressed on the adult thymocytes. To elucidate whether the developmentally ordered appearance of thymocytes expressing TcR γ/δ is dependent on the source of T cell precursors or is controlled by the thymic environment where T cells develop, we compared the expression of Vγ5 on the early‐appearing thymocytes between irradiated mice after transplantation with fetal liver (FL) cells and those after transplantation with bone marrow (BM) cells. Sequential appearance of thymocyte subpopulations was observed in the thymus of radiation FL chimeras similar to that seen in radiation BM chimeras. A substantial number of thymocytes bearing Vγ5 appeared in the thymus at the early stage of radiation FL chimeras, whereas few, if any, of such Vγ5‐bearing thymocytes were detected in the thymus at any stage of radiation BM chimeras. These results suggested that the ordered expression of Vγ repertoire may depend on the origin of the T cell precursors but not on the thymic environment.

    Original languageEnglish
    Pages (from-to)1965-1970
    Number of pages6
    JournalEuropean Journal of Immunology
    Volume20
    Issue number9
    DOIs
    Publication statusPublished - Jan 1 1990

    Fingerprint

    Thymocytes
    T-Cell Antigen Receptor
    Thymus Gland
    Transplantation
    Liver
    Radiation
    T-Lymphoid Precursor Cells
    Bone Marrow
    Controlled Environment
    Langerhans Cells
    Bone Marrow Transplantation
    Genes
    T-Lymphocytes

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Expression of T cell receptor Vγ5 in the adult thymus of irradiated mice after transplantation with fetal liver cells. / Ogimoto, Masaro; Yoshikai, Yasunobu; Matsuzaki, Goro; Matsumoto, Koji; Kishihara, Kenji; Nomoto, Kikuo.

    In: European Journal of Immunology, Vol. 20, No. 9, 01.01.1990, p. 1965-1970.

    Research output: Contribution to journalArticle

    Ogimoto, Masaro ; Yoshikai, Yasunobu ; Matsuzaki, Goro ; Matsumoto, Koji ; Kishihara, Kenji ; Nomoto, Kikuo. / Expression of T cell receptor Vγ5 in the adult thymus of irradiated mice after transplantation with fetal liver cells. In: European Journal of Immunology. 1990 ; Vol. 20, No. 9. pp. 1965-1970.
    @article{f3a8a0889c344cca9fe5cbf68ff650b8,
    title = "Expression of T cell receptor Vγ5 in the adult thymus of irradiated mice after transplantation with fetal liver cells",
    abstract = "T cell receptor (TcR) γ/δ displays limited diversity and its diversity is distinct in different stages of ontogeny and in different anatomical sites. The Vγ5 and Vδ1 gene products are preferentially expressed on the early fetal thymocytes and on Thy‐1+ dendritic epidermal cells, whereas the Vγ4 and Vδ5 gene products are abundantly expressed on the adult thymocytes. To elucidate whether the developmentally ordered appearance of thymocytes expressing TcR γ/δ is dependent on the source of T cell precursors or is controlled by the thymic environment where T cells develop, we compared the expression of Vγ5 on the early‐appearing thymocytes between irradiated mice after transplantation with fetal liver (FL) cells and those after transplantation with bone marrow (BM) cells. Sequential appearance of thymocyte subpopulations was observed in the thymus of radiation FL chimeras similar to that seen in radiation BM chimeras. A substantial number of thymocytes bearing Vγ5 appeared in the thymus at the early stage of radiation FL chimeras, whereas few, if any, of such Vγ5‐bearing thymocytes were detected in the thymus at any stage of radiation BM chimeras. These results suggested that the ordered expression of Vγ repertoire may depend on the origin of the T cell precursors but not on the thymic environment.",
    author = "Masaro Ogimoto and Yasunobu Yoshikai and Goro Matsuzaki and Koji Matsumoto and Kenji Kishihara and Kikuo Nomoto",
    year = "1990",
    month = "1",
    day = "1",
    doi = "10.1002/eji.1830200914",
    language = "English",
    volume = "20",
    pages = "1965--1970",
    journal = "European Journal of Immunology",
    issn = "0014-2980",
    publisher = "Wiley-VCH Verlag",
    number = "9",

    }

    TY - JOUR

    T1 - Expression of T cell receptor Vγ5 in the adult thymus of irradiated mice after transplantation with fetal liver cells

    AU - Ogimoto, Masaro

    AU - Yoshikai, Yasunobu

    AU - Matsuzaki, Goro

    AU - Matsumoto, Koji

    AU - Kishihara, Kenji

    AU - Nomoto, Kikuo

    PY - 1990/1/1

    Y1 - 1990/1/1

    N2 - T cell receptor (TcR) γ/δ displays limited diversity and its diversity is distinct in different stages of ontogeny and in different anatomical sites. The Vγ5 and Vδ1 gene products are preferentially expressed on the early fetal thymocytes and on Thy‐1+ dendritic epidermal cells, whereas the Vγ4 and Vδ5 gene products are abundantly expressed on the adult thymocytes. To elucidate whether the developmentally ordered appearance of thymocytes expressing TcR γ/δ is dependent on the source of T cell precursors or is controlled by the thymic environment where T cells develop, we compared the expression of Vγ5 on the early‐appearing thymocytes between irradiated mice after transplantation with fetal liver (FL) cells and those after transplantation with bone marrow (BM) cells. Sequential appearance of thymocyte subpopulations was observed in the thymus of radiation FL chimeras similar to that seen in radiation BM chimeras. A substantial number of thymocytes bearing Vγ5 appeared in the thymus at the early stage of radiation FL chimeras, whereas few, if any, of such Vγ5‐bearing thymocytes were detected in the thymus at any stage of radiation BM chimeras. These results suggested that the ordered expression of Vγ repertoire may depend on the origin of the T cell precursors but not on the thymic environment.

    AB - T cell receptor (TcR) γ/δ displays limited diversity and its diversity is distinct in different stages of ontogeny and in different anatomical sites. The Vγ5 and Vδ1 gene products are preferentially expressed on the early fetal thymocytes and on Thy‐1+ dendritic epidermal cells, whereas the Vγ4 and Vδ5 gene products are abundantly expressed on the adult thymocytes. To elucidate whether the developmentally ordered appearance of thymocytes expressing TcR γ/δ is dependent on the source of T cell precursors or is controlled by the thymic environment where T cells develop, we compared the expression of Vγ5 on the early‐appearing thymocytes between irradiated mice after transplantation with fetal liver (FL) cells and those after transplantation with bone marrow (BM) cells. Sequential appearance of thymocyte subpopulations was observed in the thymus of radiation FL chimeras similar to that seen in radiation BM chimeras. A substantial number of thymocytes bearing Vγ5 appeared in the thymus at the early stage of radiation FL chimeras, whereas few, if any, of such Vγ5‐bearing thymocytes were detected in the thymus at any stage of radiation BM chimeras. These results suggested that the ordered expression of Vγ repertoire may depend on the origin of the T cell precursors but not on the thymic environment.

    UR - http://www.scopus.com/inward/record.url?scp=0025080776&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0025080776&partnerID=8YFLogxK

    U2 - 10.1002/eji.1830200914

    DO - 10.1002/eji.1830200914

    M3 - Article

    C2 - 2120069

    AN - SCOPUS:0025080776

    VL - 20

    SP - 1965

    EP - 1970

    JO - European Journal of Immunology

    JF - European Journal of Immunology

    SN - 0014-2980

    IS - 9

    ER -