Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma

Hiroshi Inoue, Koshi Mimori, Takeshi Shiraishi, Akemi Kataoka, Noriaki Sadanaga, Hiroaki Ueo, Graham F. Barnard, Masaki Mori

Research output: Contribution to journalArticle

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Abstract

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an inhibitor of matrix metalloproteinase (MMP) in human carcinomas. TIMP-1 is thus considered to inhibit carcinoma invasion and metastasis. On the other hand, recent reports have disclosed that TIMP-1 also possesses a growth-promoting function. The clinical significance of TIMP-1 expression has not been fully determined in breast carcinoma. We thus examined the expression of TIMP-1 mRNA in tumor tissues of 100 breast carcinoma cases by a reverse transcriptase-polymerase chain reaction assay. The expression of TIMP-1 mRNA in each case was evaluated semi-quantitatively with adjustment for the TIMP-1 expression in a control breast carcinoma cell line, MCF7. There was a significant inverse correlation between the TIMP-1 expression and lymph node metastasis (p<0.05). A multivariate analysis disclosed that TIMP-1 expression status was an independent determinant factor for lymph node metastasis. In addition, the tumors with positive estrogen or progesterone receptors showed a higher TIMP-1 mRNA expression than those without the receptors, but this did not reach statistical significance. The findings suggest that the breast tumors with high TIMP-1 expression might show less malignant potential than those with low TIMP-1 expression.

Original languageEnglish
Pages (from-to)871-874
Number of pages4
JournalOncology Reports
Volume7
Issue number4
Publication statusPublished - Jul 1 2000

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Matrix Metalloproteinase 1
Tissue Inhibitor of Metalloproteinase-1
Breast Neoplasms
Neoplasm Metastasis
Messenger RNA
Lymph Nodes
Carcinoma
Matrix Metalloproteinase Inhibitors
Progesterone Receptors
Reverse Transcriptase Polymerase Chain Reaction
Estrogen Receptors
Neoplasms
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Inoue, H., Mimori, K., Shiraishi, T., Kataoka, A., Sadanaga, N., Ueo, H., ... Mori, M. (2000). Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma. Oncology Reports, 7(4), 871-874.

Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma. / Inoue, Hiroshi; Mimori, Koshi; Shiraishi, Takeshi; Kataoka, Akemi; Sadanaga, Noriaki; Ueo, Hiroaki; Barnard, Graham F.; Mori, Masaki.

In: Oncology Reports, Vol. 7, No. 4, 01.07.2000, p. 871-874.

Research output: Contribution to journalArticle

Inoue, H, Mimori, K, Shiraishi, T, Kataoka, A, Sadanaga, N, Ueo, H, Barnard, GF & Mori, M 2000, 'Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma', Oncology Reports, vol. 7, no. 4, pp. 871-874.
Inoue H, Mimori K, Shiraishi T, Kataoka A, Sadanaga N, Ueo H et al. Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma. Oncology Reports. 2000 Jul 1;7(4):871-874.
Inoue, Hiroshi ; Mimori, Koshi ; Shiraishi, Takeshi ; Kataoka, Akemi ; Sadanaga, Noriaki ; Ueo, Hiroaki ; Barnard, Graham F. ; Mori, Masaki. / Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma. In: Oncology Reports. 2000 ; Vol. 7, No. 4. pp. 871-874.
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