Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer

Kyoko Okamura, Taishi Harada, Shuo Wang, Kayo Ijichi, Kazuto Furuyama, Takaomi Koga, Tatsuro Okamoto, Koichi Takayama, Tokujiro Yano, Yoichi Nakanishi

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

High expression levels of TrkB and BDNF are associated with aggressive malignant behavior in tumor cells and a poor prognosis in patients with various types of cancer. In this study, we aimed to identify the relationship between TrkB and BDNF expression and clinicopathological variables and prognosis in non-small cell lung cancer (NSCLC). We evaluated TrkB and BDNF expression in the tumor cells of 102 NSCLC patients by immunohistochemistry. Out of all clinicopathological factors examined, only vascular invasion was significantly correlated with TrkB (P= 0.010) and BDNF (P= 0.015) expression. TrkB-positive tumors had significantly worse disease-free survival (P= 0.0094) and overall survival (P= 0.0019) than TrkB-negative tumors, and TrkB expression was an independent prognostic factor for disease-free survival (HR 3.735, 95%C.I. 1.560-11.068, P= 0.002) and overall survival (HR 4.335, 95%C.I. 1.534-15.963, P= 0.004) in multivariate analysis. Finally, our analysis revealed that co-expression of TrkB and BDNF conferred poorer prognosis compared with overexpression of either protein alone. Our results indicate that expression of TrkB and BDNF is associated with poor prognosis in NSCLC patients.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalLung Cancer
Volume78
Issue number1
DOIs
Publication statusPublished - Oct 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Fingerprint Dive into the research topics of 'Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer'. Together they form a unique fingerprint.

Cite this