Expression profile of class I histone deacetylases in human cancer tissues

Masamune Nakagawa, Yoshinao Oda, Takashi Eguchi, Shin Ichi Aishima, Takashi Yao, Fumihito Hosoi, Yuji Basaki, Mayumi Ono, Michihiko Kuwano, Masao Tanaka, Masazumi Tsuneyoshi

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232 Citations (Scopus)

Abstract

Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.

Original languageEnglish
Pages (from-to)769-774
Number of pages6
JournalOncology reports
Volume18
Issue number4
Publication statusPublished - Oct 1 2007

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Nakagawa, M., Oda, Y., Eguchi, T., Aishima, S. I., Yao, T., Hosoi, F., ... Tsuneyoshi, M. (2007). Expression profile of class I histone deacetylases in human cancer tissues. Oncology reports, 18(4), 769-774.