Extension of the lifespan of caenorhabditis elegans by the use of electrolyzed reduced water

Hanxu Yan, Huaize Tian, Tomoya Kinjo, Takeki Hamasaki, Kosuke Tomimatsu, Noboru Nakamichi, Kiichiro Teruya, Shigeru Kabayama, Sanetaka Shirahata

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Electrolyzed reduced water (ERW) has attracted much attention because of its therapeutic effects. In the present study, a new culture medium, which we designated Water medium, was developed to elucidate the effects of ERW on the lifespan of Caenorhabditis elegans. Wild-type C. elegans had a significantly shorter lifespan in Water medium than in conventional S medium. However, worms cultured in ERW-Water medium exhibited a significantly extended lifespan (from 11% to 41%) compared with worms cultured in ultrapure water-Water medium. There was no difference between the lifespans of worms cultured in ERW-S medium and ultrapure water-S medium. Nematodes cultured in ultrapure water-Water medium showed significantly higher levels of reactive oxygen species than those cultured in ultrapure water-S medium. Moreover, ERW-Water medium significantly reduced the ROS accumulation induced in the worms by paraquat, suggesting that ERW-Water medium extends the longevity of nematodes at least partly by scavenging ROS.

Original languageEnglish
Pages (from-to)2011-2015
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number10
DOIs
Publication statusPublished - Nov 8 2010

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Caenorhabditis elegans
Water
Paraquat
Scavenging
Therapeutic Uses

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Yan, H., Tian, H., Kinjo, T., Hamasaki, T., Tomimatsu, K., Nakamichi, N., ... Shirahata, S. (2010). Extension of the lifespan of caenorhabditis elegans by the use of electrolyzed reduced water. Bioscience, Biotechnology and Biochemistry, 74(10), 2011-2015. https://doi.org/10.1271/bbb.100250

Extension of the lifespan of caenorhabditis elegans by the use of electrolyzed reduced water. / Yan, Hanxu; Tian, Huaize; Kinjo, Tomoya; Hamasaki, Takeki; Tomimatsu, Kosuke; Nakamichi, Noboru; Teruya, Kiichiro; Kabayama, Shigeru; Shirahata, Sanetaka.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 10, 08.11.2010, p. 2011-2015.

Research output: Contribution to journalArticle

Yan, H, Tian, H, Kinjo, T, Hamasaki, T, Tomimatsu, K, Nakamichi, N, Teruya, K, Kabayama, S & Shirahata, S 2010, 'Extension of the lifespan of caenorhabditis elegans by the use of electrolyzed reduced water', Bioscience, Biotechnology and Biochemistry, vol. 74, no. 10, pp. 2011-2015. https://doi.org/10.1271/bbb.100250
Yan, Hanxu ; Tian, Huaize ; Kinjo, Tomoya ; Hamasaki, Takeki ; Tomimatsu, Kosuke ; Nakamichi, Noboru ; Teruya, Kiichiro ; Kabayama, Shigeru ; Shirahata, Sanetaka. / Extension of the lifespan of caenorhabditis elegans by the use of electrolyzed reduced water. In: Bioscience, Biotechnology and Biochemistry. 2010 ; Vol. 74, No. 10. pp. 2011-2015.
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