Extracellular matrix gene regulation

Ken Okazaki, Linda J. Sandell

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Extracellular matrix metabolism plays a central role in development of skeletal tissues and in most orthopaedic diseases and trauma such as fracture or osteotomy repair, arthritis, cartilage repair, and congenital skeletal deformity. During development or disease, specific genes must be expressed in order to make or repair appropriate extracellular matrix. For example, specific gene expression patterns are characteristic of bone and cartilage. The precise expression pattern depends on a balance of positive and negative transcription factors, proteins that control the synthesis of mRNA from the specific gene. In cartilage, a number of studies indicate that Sox transcription factors are critical positive regulators in genes such as COL2A1, COL9A2, COL11A2, aggrecan, and CD-RAP. In addition, negative regulators are also essential to fine tune gene regulation in chondrocytes and to turn off gene expression in noncartilaginous tissues. Negative transcription factors in cartilage include ∂EF-1, snail/slug, CYRBP1, NT2, and C/EBP. Runx2 and osterix are critical transcription factors for osteogenesis but also have some influence on chondrogenesis. The availability of cis-regulatory sites in specific genes combined with the availability of transcription factors in the nucleus deter-mines the level of gene expression.

Original languageEnglish
JournalClinical Orthopaedics and Related Research
Issue number427 SUPPL.
DOIs
Publication statusPublished - Oct 1 2004

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Extracellular Matrix
Transcription Factors
Cartilage
Genes
Gene Expression
Peptide Elongation Factor 1
Aggrecans
Chondrogenesis
Gastropoda
Snails
Regulator Genes
Chondrocytes
Osteotomy
Osteogenesis
Arthritis
Orthopedics
Bone and Bones
Messenger RNA
Wounds and Injuries
Proteins

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Extracellular matrix gene regulation. / Okazaki, Ken; Sandell, Linda J.

In: Clinical Orthopaedics and Related Research, No. 427 SUPPL., 01.10.2004.

Research output: Contribution to journalArticle

Okazaki, Ken ; Sandell, Linda J. / Extracellular matrix gene regulation. In: Clinical Orthopaedics and Related Research. 2004 ; No. 427 SUPPL.
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