Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs

Toyokazu Uwatoku, Kenta Ito, Kotaro Abe, Keiji Oi, Takatoshi Hizume, Kenji Sunagawa, Hiroaki Shimokawa

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Abstract

OBJECTIVE: We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS: Acute myocardial infarction was created by surgically excising the proximal segment of the left circumflex coronary artery (n=20). In the early treatment protocol, the shock wave therapy was started 3 days after acute myocardial infarction, whereas in the late treatment protocol, the therapy was started 4 weeks after acute myocardial infarction (n=5 each). The remaining animals were treated in the same manner, but without the shock wave treatment in each protocol (n=5 each). RESULTS: In the early treatment protocol, left ventricular ejection fraction was higher (42±1 vs. 32±1%, P<0.001) and left ventricular end-diastolic volume was smaller (95±1 vs. 99±2 ml, P<0.05) in the shock wave group compared with the control group. Furthermore, wall thickening fraction (32±1 vs. 28±1%, P<0.01), regional myocardial blood flow (1.7±0.2 vs. 1.0±0.1 ml/min/g, P<0.01), and number of capillaries in the border zone (1348±15 vs. 938±34 mm, P<0.0001) were all significantly improved in the shock wave group compared with the control group. By contrast, in the late treatment group, no such beneficial effects of the shock wave therapy were noted. CONCLUSION: These results suggest that our extracorporeal cardiac shock wave therapy is also an effective and noninvasive therapy for improving left ventricular remodeling after acute myocardial infarction when started in the early phase of the disorder.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalCoronary Artery Disease
Volume18
Issue number5
DOIs
Publication statusPublished - Aug 2007

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Convulsive Therapy
Ventricular Remodeling
Swine
Myocardial Infarction
Clinical Protocols
Stroke Volume
Control Groups
Regional Blood Flow
Therapeutics
Myocardial Ischemia
Coronary Vessels

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. / Uwatoku, Toyokazu; Ito, Kenta; Abe, Kotaro; Oi, Keiji; Hizume, Takatoshi; Sunagawa, Kenji; Shimokawa, Hiroaki.

In: Coronary Artery Disease, Vol. 18, No. 5, 08.2007, p. 397-404.

Research output: Contribution to journalArticle

Uwatoku, Toyokazu ; Ito, Kenta ; Abe, Kotaro ; Oi, Keiji ; Hizume, Takatoshi ; Sunagawa, Kenji ; Shimokawa, Hiroaki. / Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. In: Coronary Artery Disease. 2007 ; Vol. 18, No. 5. pp. 397-404.
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abstract = "OBJECTIVE: We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS: Acute myocardial infarction was created by surgically excising the proximal segment of the left circumflex coronary artery (n=20). In the early treatment protocol, the shock wave therapy was started 3 days after acute myocardial infarction, whereas in the late treatment protocol, the therapy was started 4 weeks after acute myocardial infarction (n=5 each). The remaining animals were treated in the same manner, but without the shock wave treatment in each protocol (n=5 each). RESULTS: In the early treatment protocol, left ventricular ejection fraction was higher (42±1 vs. 32±1{\%}, P<0.001) and left ventricular end-diastolic volume was smaller (95±1 vs. 99±2 ml, P<0.05) in the shock wave group compared with the control group. Furthermore, wall thickening fraction (32±1 vs. 28±1{\%}, P<0.01), regional myocardial blood flow (1.7±0.2 vs. 1.0±0.1 ml/min/g, P<0.01), and number of capillaries in the border zone (1348±15 vs. 938±34 mm, P<0.0001) were all significantly improved in the shock wave group compared with the control group. By contrast, in the late treatment group, no such beneficial effects of the shock wave therapy were noted. CONCLUSION: These results suggest that our extracorporeal cardiac shock wave therapy is also an effective and noninvasive therapy for improving left ventricular remodeling after acute myocardial infarction when started in the early phase of the disorder.",
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N2 - OBJECTIVE: We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS: Acute myocardial infarction was created by surgically excising the proximal segment of the left circumflex coronary artery (n=20). In the early treatment protocol, the shock wave therapy was started 3 days after acute myocardial infarction, whereas in the late treatment protocol, the therapy was started 4 weeks after acute myocardial infarction (n=5 each). The remaining animals were treated in the same manner, but without the shock wave treatment in each protocol (n=5 each). RESULTS: In the early treatment protocol, left ventricular ejection fraction was higher (42±1 vs. 32±1%, P<0.001) and left ventricular end-diastolic volume was smaller (95±1 vs. 99±2 ml, P<0.05) in the shock wave group compared with the control group. Furthermore, wall thickening fraction (32±1 vs. 28±1%, P<0.01), regional myocardial blood flow (1.7±0.2 vs. 1.0±0.1 ml/min/g, P<0.01), and number of capillaries in the border zone (1348±15 vs. 938±34 mm, P<0.0001) were all significantly improved in the shock wave group compared with the control group. By contrast, in the late treatment group, no such beneficial effects of the shock wave therapy were noted. CONCLUSION: These results suggest that our extracorporeal cardiac shock wave therapy is also an effective and noninvasive therapy for improving left ventricular remodeling after acute myocardial infarction when started in the early phase of the disorder.

AB - OBJECTIVE: We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS: Acute myocardial infarction was created by surgically excising the proximal segment of the left circumflex coronary artery (n=20). In the early treatment protocol, the shock wave therapy was started 3 days after acute myocardial infarction, whereas in the late treatment protocol, the therapy was started 4 weeks after acute myocardial infarction (n=5 each). The remaining animals were treated in the same manner, but without the shock wave treatment in each protocol (n=5 each). RESULTS: In the early treatment protocol, left ventricular ejection fraction was higher (42±1 vs. 32±1%, P<0.001) and left ventricular end-diastolic volume was smaller (95±1 vs. 99±2 ml, P<0.05) in the shock wave group compared with the control group. Furthermore, wall thickening fraction (32±1 vs. 28±1%, P<0.01), regional myocardial blood flow (1.7±0.2 vs. 1.0±0.1 ml/min/g, P<0.01), and number of capillaries in the border zone (1348±15 vs. 938±34 mm, P<0.0001) were all significantly improved in the shock wave group compared with the control group. By contrast, in the late treatment group, no such beneficial effects of the shock wave therapy were noted. CONCLUSION: These results suggest that our extracorporeal cardiac shock wave therapy is also an effective and noninvasive therapy for improving left ventricular remodeling after acute myocardial infarction when started in the early phase of the disorder.

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