Extranodal Multiple Involvement of Enteropathy-Type T-Cell Lymphoma without Expression of CC Chemokine Receptor 7

Motoaki Shiratsuchi, Youko Suehiro, Yasuji Yoshikawa, Koichi Ohshima, Satoshi Shiokawa, Junji Nishimura

Research output: Contribution to journalArticle

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Abstract

Enteropathy-type T-cell lymphoma (ETCL) is a rare extranodal lymphoma that tends to disseminate into the intestines and other extranodal organs. We present a case of ETCL with involvement of the lungs and kidneys and report CC chemokine receptor 7 (CCR7) expression of lymphoma cells. A 73-year-old man was admitted to the hospital with a complaint of abdominal pain. Multiple ulcers and perforations were observed in the small intestine, and partial resection of the ileum was performed. Histological examination of the resected specimen revealed diffuse proliferation of atypical large lymphoid cells. The diagnosis was ETCL with dissemination into the lungs and kidney. Lymphoma cells of the small intestine and in pleural effusion were CD3+, CD4+, CD7+, CD8-, CD25-, CD56-, CD103 +/-, and TIA-1+. Rearrangement of the T-cell receptor β gene was detected, and human T-lymphotropic virus was not integrated. Combination chemotherapy did not result in a sustained response. The results for CCR7 expression of lymphoma cells in the lung and pleural effusion were negative. Therefore we concluded that lymphoma cells did not migrate into the lymph nodes but instead spread into the extranodal organs.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalInternational journal of hematology
Volume79
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

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CCR7 Receptors
T-Cell Lymphoma
Lymphoma
Pleural Effusion
Lung
Small Intestine
Kidney
T-Cell Receptor Genes
Combination Drug Therapy
Ileum
Abdominal Pain
Ulcer
Intestines
Lymph Nodes
Lymphocytes
Viruses

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Extranodal Multiple Involvement of Enteropathy-Type T-Cell Lymphoma without Expression of CC Chemokine Receptor 7. / Shiratsuchi, Motoaki; Suehiro, Youko; Yoshikawa, Yasuji; Ohshima, Koichi; Shiokawa, Satoshi; Nishimura, Junji.

In: International journal of hematology, Vol. 79, No. 1, 01.01.2004, p. 44-47.

Research output: Contribution to journalArticle

Shiratsuchi, Motoaki ; Suehiro, Youko ; Yoshikawa, Yasuji ; Ohshima, Koichi ; Shiokawa, Satoshi ; Nishimura, Junji. / Extranodal Multiple Involvement of Enteropathy-Type T-Cell Lymphoma without Expression of CC Chemokine Receptor 7. In: International journal of hematology. 2004 ; Vol. 79, No. 1. pp. 44-47.
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