Extraosseous accumulation of 99mTc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma

Koichiro Abe; Masayuki Sasaki; Yasuo Kuwabara; Hirofumi Koga; Shingo Baba; Koichiro Kaneko; Kazutaka Hayashi; Yoshiyuki Shioyama; Tatsuro Tajiri; Sachiyo Suita; Hiroshi Honda

doi:10.1007/BF02986333

Extraosseous accumulation of ^99mTc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma

Koichiro Abe, Masayuki Sasaki, Yasuo Kuwabara, Hirofumi Koga, Shingo Baba, Koichiro Kaneko, Kazutaka Hayashi, Yoshiyuki Shioyama, Tatsuro Tajiri, Sachiyo Suita, Hiroshi Honda

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Objective: The aim of this study is to clarify the period of extraosseous accumulation of ^99mTc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region. Methods: We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent ^99mTc-HMDP bone scintigraphies periodically before and after radiation therapy. Results: Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from O to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of ^99mTc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy. Conclusion: When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Annals of Nuclear Medicine
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/BF02986333
Publication status	Published - Feb 2005

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1007/BF02986333

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title = "Extraosseous accumulation of 99mTc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma",

abstract = "Objective: The aim of this study is to clarify the period of extraosseous accumulation of 99mTc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region. Methods: We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent 99mTc-HMDP bone scintigraphies periodically before and after radiation therapy. Results: Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from O to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of 99mTc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy. Conclusion: When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.",

author = "Koichiro Abe and Masayuki Sasaki and Yasuo Kuwabara and Hirofumi Koga and Shingo Baba and Koichiro Kaneko and Kazutaka Hayashi and Yoshiyuki Shioyama and Tatsuro Tajiri and Sachiyo Suita and Hiroshi Honda",

year = "2005",

month = feb,

doi = "10.1007/BF02986333",

language = "English",

volume = "19",

pages = "35--40",

journal = "Annals of Nuclear Medicine",

issn = "0914-7187",

publisher = "Springer Japan",

number = "1",

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TY - JOUR

T1 - Extraosseous accumulation of 99mTc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma

AU - Abe, Koichiro

AU - Sasaki, Masayuki

AU - Kuwabara, Yasuo

AU - Koga, Hirofumi

AU - Baba, Shingo

AU - Kaneko, Koichiro

AU - Hayashi, Kazutaka

AU - Shioyama, Yoshiyuki

AU - Tajiri, Tatsuro

AU - Suita, Sachiyo

AU - Honda, Hiroshi

PY - 2005/2

Y1 - 2005/2

N2 - Objective: The aim of this study is to clarify the period of extraosseous accumulation of 99mTc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region. Methods: We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent 99mTc-HMDP bone scintigraphies periodically before and after radiation therapy. Results: Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from O to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of 99mTc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy. Conclusion: When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.

AB - Objective: The aim of this study is to clarify the period of extraosseous accumulation of 99mTc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region. Methods: We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent 99mTc-HMDP bone scintigraphies periodically before and after radiation therapy. Results: Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from O to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of 99mTc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy. Conclusion: When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.

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U2 - 10.1007/BF02986333

DO - 10.1007/BF02986333

M3 - Review article

C2 - 15770971

AN - SCOPUS:20144381960

VL - 19

SP - 35

EP - 40

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 1

ER -

Extraosseous accumulation of ^99mTc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma

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