TY - GEN
T1 - Extravasation of soft nanoparticles simulated on an easy-to-observe membrane-integrated microfluidic device
AU - Watanabe, Mayu
AU - Moriya, Yumi
AU - Matsuba, Hiroaki
AU - Kishimura, Akihiro
AU - Katayama, Yoshiki
AU - Sasaki, Naoki
N1 - Funding Information:
This work was supported in part by JSPS KAKENHI Grant Number JP19K05236 and JP18H03534.
Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - Nanoparticles with diameters of ~100 nm have been widely utilized for tumor-targeted drug delivery. Recently, soft nanoparticles have been recognized as better drug carriers than hard ones. However, the effect of nanoparticle elasticity on the extravasation has not been clarified yet. Here we simulate extravasation of soft nanoparticles using our easy-to-observe membrane-integrated microfluidic device. Soft nanoparticles exhibit higher permeability compared to hard one. The present technique will be utilized to clarify the mechanism of drug delivery by soft nanoparticles and to evaluate the performance of the nanoparticles prior to animal testing.
AB - Nanoparticles with diameters of ~100 nm have been widely utilized for tumor-targeted drug delivery. Recently, soft nanoparticles have been recognized as better drug carriers than hard ones. However, the effect of nanoparticle elasticity on the extravasation has not been clarified yet. Here we simulate extravasation of soft nanoparticles using our easy-to-observe membrane-integrated microfluidic device. Soft nanoparticles exhibit higher permeability compared to hard one. The present technique will be utilized to clarify the mechanism of drug delivery by soft nanoparticles and to evaluate the performance of the nanoparticles prior to animal testing.
UR - http://www.scopus.com/inward/record.url?scp=85094956794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094956794&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85094956794
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 750
EP - 751
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -