Extravasation of soft nanoparticles simulated on an easy-to-observe membrane-integrated microfluidic device

Mayu Watanabe, Yumi Moriya, Hiroaki Matsuba, Akihiro Kishimura, Yoshiki Katayama, Naoki Sasaki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoparticles with diameters of ~100 nm have been widely utilized for tumor-targeted drug delivery. Recently, soft nanoparticles have been recognized as better drug carriers than hard ones. However, the effect of nanoparticle elasticity on the extravasation has not been clarified yet. Here we simulate extravasation of soft nanoparticles using our easy-to-observe membrane-integrated microfluidic device. Soft nanoparticles exhibit higher permeability compared to hard one. The present technique will be utilized to clarify the mechanism of drug delivery by soft nanoparticles and to evaluate the performance of the nanoparticles prior to animal testing.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages750-751
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period10/27/1910/31/19

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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