TY - JOUR
T1 - F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation
AU - Yumimoto, Kanae
AU - Matsumoto, Masaki
AU - Onoyama, Ichiro
AU - Imaizumi, Kazunori
AU - Nakayama, Keiichi I.
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.
AB - Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.
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U2 - 10.1074/jbc.M113.465179
DO - 10.1074/jbc.M113.465179
M3 - Article
C2 - 23955342
AN - SCOPUS:84885165994
VL - 288
SP - 28488
EP - 28502
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 40
ER -