F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Kanae Yumimoto, Masaki Matsumoto, Ichiro Onoyama, Kazunori Imaizumi, Keiichi I. Nakayama

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.

Original languageEnglish
Pages (from-to)28488-28502
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - Oct 4 2013

Fingerprint

Chondrogenesis
Osteogenesis
Endoplasmic Reticulum
SKP Cullin F-Box Protein Ligases
F-Box Proteins
Degradation
Neoplastic Stem Cells
Stem cells
Tumors
Proteins
Transcription Factors
Maintenance
Substrates
WD40 Repeats
poly(divinyl-co-N-vinylpyrrolidinone)

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.",
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T1 - F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

AU - Yumimoto, Kanae

AU - Matsumoto, Masaki

AU - Onoyama, Ichiro

AU - Imaizumi, Kazunori

AU - Nakayama, Keiichi I.

PY - 2013/10/4

Y1 - 2013/10/4

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AB - Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.

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