F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Kanae Yumimoto, Masaki Matsumoto, Ichiro Onoyama, Kazunori Imaizumi, Keiichi I. Nakayama

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.

Original languageEnglish
Pages (from-to)28488-28502
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - Oct 4 2013

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Chondrogenesis
Osteogenesis
Endoplasmic Reticulum
SKP Cullin F-Box Protein Ligases
F-Box Proteins
Degradation
Neoplastic Stem Cells
Stem cells
Tumors
Proteins
Transcription Factors
Maintenance
Substrates
WD40 Repeats
poly(divinyl-co-N-vinylpyrrolidinone)

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. / Yumimoto, Kanae; Matsumoto, Masaki; Onoyama, Ichiro; Imaizumi, Kazunori; Nakayama, Keiichi I.

In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 28488-28502.

Research output: Contribution to journal › Article

Yumimoto, K, Matsumoto, M, Onoyama, I, Imaizumi, K & Nakayama, KI 2013, 'F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation', Journal of Biological Chemistry, vol. 288, no. 40, pp. 28488-28502. https://doi.org/10.1074/jbc.M113.465179
Yumimoto K, Matsumoto M, Onoyama I, Imaizumi K, Nakayama KI. F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. Journal of Biological Chemistry. 2013 Oct 4;288(40):28488-28502. https://doi.org/10.1074/jbc.M113.465179
Yumimoto, Kanae ; Matsumoto, Masaki ; Onoyama, Ichiro ; Imaizumi, Kazunori ; Nakayama, Keiichi I. / F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 40. pp. 28488-28502.
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