F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Kanae Yumimoto; Masaki Matsumoto; Ichiro Onoyama; Kazunori Imaizumi; Keiichi I. Nakayama

doi:10.1074/jbc.M113.465179

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Kanae Yumimoto, Masaki Matsumoto, Ichiro Onoyama, Kazunori Imaizumi, Keiichi I. Nakayama

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.

Original language	English
Pages (from-to)	28488-28502
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.465179
Publication status	Published - Oct 4 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. / Yumimoto, Kanae; Matsumoto, Masaki; Onoyama, Ichiro; Imaizumi, Kazunori; Nakayama, Keiichi I.

In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 28488-28502.

Research output: Contribution to journal › Article › peer-review

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AU - Imaizumi, Kazunori

AU - Nakayama, Keiichi I.

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