Background:Fbxw7 is the F-box protein component of an SCF-type ubiquitin ligase that plays key roles in tumor suppression and stem cell maintenance. Results:The transcription factors OASIS and BBF2H7 were identified as new substrates of Fbxw7. Conclusion:Fbxw7 controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 for degradation. Significance:Fbxw7 is an important regulator of osteogenesis and chondrogenesis.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology