Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method

Daisuke Ohsato, Masaru Tanaka, Sadaaki Yamamoto, Takeshi Higuchi, Hiroshi Yabu, Masatsugu Shimomura

Research output: Contribution to conferencePaper

Abstract

Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 19 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period5/24/065/26/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Ohsato, D., Tanaka, M., Yamamoto, S., Higuchi, T., Yabu, H., & Shimomura, M. (2006). Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.