Fabrication and characterization of quartz nanopillars for DNA separation by size

Ryo Ogawa; Noritada Kaji; Shingi Hashioka; Yoshinobu Baba; Yasuhiro Horiike

doi:10.1143/JJAP.46.2771

Fabrication and characterization of quartz nanopillars for DNA separation by size

Ryo Ogawa, Noritada Kaji, Shingi Hashioka, Yoshinobu Baba, Yasuhiro Horiike

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We fabricated two different distributions of nanopillars-tilted and square distributions. There are difficulties in fabricating a chip containing these nanopillars, particularly in Ni plating and quartz bonding. We improved the Ni plating by applying stable electric current and the reliability of the quartz bonding. In nanopillars with a square distribution, DNA showed conformational changes, and did not show any reptile motion, but moved in a straight line in contrast with its behavior in nanopillars with a tilted distribution. Nanopillars with a tilted distribution acted effectively as sieves for DNA separation by size.

Original language	English
Pages (from-to)	2771-2774
Number of pages	4
Journal	Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Volume	46
Issue number	4 B
DOIs	https://doi.org/10.1143/JJAP.46.2771
Publication status	Published - Apr 24 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Engineering(all)
Physics and Astronomy(all)

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10.1143/JJAP.46.2771

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AU - Kaji, Noritada

AU - Hashioka, Shingi

AU - Baba, Yoshinobu

AU - Horiike, Yasuhiro

PY - 2007/4/24

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AB - We fabricated two different distributions of nanopillars-tilted and square distributions. There are difficulties in fabricating a chip containing these nanopillars, particularly in Ni plating and quartz bonding. We improved the Ni plating by applying stable electric current and the reliability of the quartz bonding. In nanopillars with a square distribution, DNA showed conformational changes, and did not show any reptile motion, but moved in a straight line in contrast with its behavior in nanopillars with a tilted distribution. Nanopillars with a tilted distribution acted effectively as sieves for DNA separation by size.

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Fabrication and characterization of quartz nanopillars for DNA separation by size

Abstract

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